Stem cells are characterized by their dual ability to reproduce themselves (self‐renew) and
specialize (differentiate), yielding a plethora of daughter cells that maintain and regenerate …

Stem cell-based therapeutics have become a vital component in tissue engineering and
regenerative medicine. The microenvironment within which stem cells reside, ie, the niche …

Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues
and self-renew, hold great promise for both regenerative medicine and novel therapeutic …

In the body, tissue homeostasis is established and maintained by resident tissue-specific
adult stem cells (aSCs). Through preservation of bidirectional communications with the …

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and
current knowledge on embryonic and adult stem cell niches, focusing on the understanding …

The stem cell niche is an anatomical site that contains a reservoir of multipotent stem cells
(SCs) that can maintain normal tissue, or replenish injured or aged cell populations, in …

The potential for the clinical application of stem cells in tissue regeneration is clearly
significant. However, this potential has remained largely unrealized owing to the persistent …

Biomaterials are increasingly being developed as in vitro microenvironments mimicking in
vivo stem cell niches. However, current macroscale methodologies to produce these niche …

Within the adult organism, stem cells reside in defined anatomical microenvironments called
niches. These architecturally diverse microenvironments serve to balance stem cell self …

Although researchers currently have limited ability to mimic the natural stem cell
microenvironment, recent work at the interface of stem biology and biomaterials science has …