Publisher Summary This chapter discusses the structural aspects and structure–activity
relationships of heparin/heparan sulfate (HS). The molecular mechanism behind the …

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been
and continue to be a major scientific undertaking-heparin and its derivative remain important …

The sulfated polysaccharide heparin has been used as a life-saving anticoagulant in clinics
well before its detailed structure was known. This mini-review is a survey of the evolution in …

Heparin, a sulfated polysaccharide, is a major clinical anticoagulant. It is exploited to
overcome the natural propensity for blood to clot. Surgical procedures often require …

This book describes the complex structures of heparins and heparan sulfates (heparinoids)
and how they are generated by their biosynthetic pathways. The book also details the …

Issues of nomenclature are rarely inspiring; the main emphasis of this presentation will in
fact be on the biosynthesis rather than on the designation of" heparin-like polysaccharides" …

Heparin has been used extensively in the clinical setting as an anticoagulant. The properties
of this polymer were first noted by McLean during his second year as a medical student at …

The rapid preparation of multimilligram quantities of five heparin-derived oligosaccharides
(1–5) is described. These oligosaccharides are the final products obtained from the action of …

Heparan sulfate (HS) is present on the surface of endothelial and surrounding tissues in
large quantities. It plays important roles in regulating numerous functions of the blood vessel …

RJ Linhardt,**'* JE Turnbull, § HM Wang,* D. Loganathan,* and JT Gallagher11 Division of
Medicinal and Natural Products Chemistry, College of Pharmacy, University of Iowa, Iowa …