Background: Breast cancer is the leading cause of cancer related death in women
worldwide. The development of metastatic cancer is the main factor contributing to mortality …

Cancer is one of the biggest leading causes of death worldwide. With increased
accumulation of environmental factors like radiation and mutagens, causative mutation in …

The extracellular matrix (ECM) is a complex network of secreted proteins which provides
support for tissues and organs. Additionally, the ECM controls a plethora of cell functions …

Cancer cells are confronted with nutrient deprivation because of high proliferation rate,
especially at the early stage of their development. There is a frequent assumption that …

Nutrient deprivation strategies have been proposed as an adjuvant therapy for cancer cells
due to their increased metabolic demand. We examined the specific inhibitory effects of …

Breast cancer has the highest incidence rate of malignancy in women worldwide. A major
clinical challenge faced by patients with breast cancer treated by conventional therapies is …

Background The seed and soil hypothesis was proposed over a century ago to describe why
cancer cells (seeds) grow in certain organs (soil). Since then, the genetic properties that …

Distant metastasis to specific target organs is responsible for over 90% of breast cancer-
related deaths, but the underlying molecular mechanism is unclear. Mounting evidence …

Cancer cell progression and proliferation increase cell density, resulting in changes to the
tumour site, including the microenvironment. What is not known is if increased cell density …

Cancerous cells display metabolic engineering through enhanced utilization of nutrients to
support their increased requirements for proliferation, bioenergetics, biosynthesis, redox …