The fungal exopolysaccharide galactosaminogalactan mediates virulence by enhancing resistance to neutrophil extracellular traps

MJ Lee, H Liu, BM Barker, BD Snarr, FN Gravelat… - PLoS …, 2015 - journals.plos.org
Of the over 250 Aspergillus species, Aspergillus fumigatus accounts for up to 80% of
invasive human infections. A. fumigatus produces galactosaminogalactan (GAG), an …

Aspergillus Galactosaminogalactan Mediates Adherence to Host Constituents and Conceals Hyphal β-Glucan from the Immune System

FN Gravelat, A Beauvais, H Liu, MJ Lee… - PLoS …, 2013 - journals.plos.org
Aspergillus fumigatus is the most common cause of invasive mold disease in humans. The
mechanisms underlying the adherence of this mold to host cells and macromolecules have …

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

MS Gresnigt, S Bozza, KL Becker, LAB Joosten… - PLoS …, 2014 - journals.plos.org
The galactosaminogalactan (GAG) is a cell wall component of Aspergillus fumigatus that has
potent anti-inflammatory effects in mice. However, the mechanisms responsible for the anti …

Galactosaminogalactan (GAG) and its multiple roles in Aspergillus pathogenesis

C Speth, G Rambach, C Lass-Flörl, PL Howell… - Virulence, 2019 - Taylor & Francis
Aspergillus spp and particularly the species Aspergillus fumigatus are the causative agents
of invasive aspergillosis, a progressive necrotizing pneumonia that occurs in …

Aspergillus fumigatus LaeA-Mediated Phagocytosis Is Associated with a Decreased Hydrophobin Layer

TRT Dagenais, SS Giles, V Aimanianda… - Infection and …, 2010 - Am Soc Microbiol
Aspergillus fumigatus is the causal agent of the life-threatening disease invasive
aspergillosis. A. fumigatus laeA deletants, aberrant in toxin biosynthesis and spore …

Deacetylation of fungal exopolysaccharide mediates adhesion and biofilm formation

MJ Lee, AM Geller, NC Bamford, H Liu, FN Gravelat… - MBio, 2016 - Am Soc Microbiol
The mold Aspergillus fumigatus causes invasive infection in immunocompromised patients.
Recently, galactosaminogalactan (GAG), an exopolysaccharide composed of galactose and …

Galectin-3 enhances neutrophil motility and extravasation into the airways during Aspergillus fumigatus infection

BD Snarr, G St-Pierre, B Ralph, M Lehoux… - PLoS …, 2020 - journals.plos.org
Aspergillus fumigatus is an opportunistic mold that infects patients who are
immunocompromised or have chronic lung disease, causing significant morbidity and …

Ega3 from the fungal pathogen Aspergillus fumigatus is an endo-α-1, 4-galactosaminidase that disrupts microbial biofilms

NC Bamford, F Le Mauff, AS Subramanian, P Yip… - Journal of Biological …, 2019 - ASBMB
Aspergillus fumigatus is an opportunistic fungal pathogen that causes both chronic and
acute invasive infections. Galactosaminogalactan (GAG) is an integral component of the A …

Recent advances in the understanding of the Aspergillus fumigatus cell wall

MJ Lee, DC Sheppard - Journal of microbiology, 2016 - Springer
Over the past several decades, research on the synthesis and organization of the cell wall
polysaccharides of Aspergillus fumigatus has expanded our knowledge of this important …

Galactosaminogalactan, a New Immunosuppressive Polysaccharide of Aspergillus fumigatus

T Fontaine, A Delangle, C Simenel, B Coddeville… - PLoS …, 2011 - journals.plos.org
A new polysaccharide secreted by the human opportunistic fungal pathogen Aspergillus
fumigatus has been characterized. Carbohydrate analysis using specific chemical …