The microenvironmental physiology of tumors is uniquely different from that of normal
tissues. It is characterized, inter alia, by O2 depletion (hypoxia, anoxia), glucose and energy …

Poor microenvironmental conditions are a characteristic feature of solid tumors. Such
conditions occur because the tumor vascular supply, which develops from the normal host …

The microenvironment of solid human tumors is characterized by heterogeneity in
oxygenation. Hypoxia arises early in the process of tumor development because rapidly …

Many human tumors contain a significant fraction of hypoxic cells that can directly affect
responsiveness to therapy. Evidence is increasing that hypoxia may also contribute to …

The results from many studies indicate that most solid tumors, regardless of site of origin,
contain hypoxic regions. Experimental studies have demonstrated that, apart from the well …

Metastasis is not the result of a random event, as cancer cells can sustain and proliferate
actively only in a suitable tissue microenvironment and then form metastases. Since Dr …

One of the major advances in cancer research over the last several decades has been the
growing (but still far from universal) recognition that adaptation of the cancer cell to its …

There is overwhelming evidence that solid human tumours grow within a unique micro-
environment. This environment is characterised by an abnormal vasculature, which leads to …

Growing evidence from experimental and clinical studies points to the fundamental,
pathophysiologic role of hypoxia in solid tumors. Intratumoral hypoxia is a consequence of a …

Hypoxia or low oxygen concentration in tumor microenvironment has widespread effects
ranging from altered angiogenesis and lymphangiogenesis, tumor metabolism, growth, and …