[HTML][HTML] Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin
C Orlik, D Deibel, J Küblbeck, E Balta… - Cellular & Molecular …, 2020 - nature.com
The interplay between keratinocytes and immune cells, especially T cells, plays an important
role in the pathogenesis of chronic inflammatory skin diseases. During psoriasis …
role in the pathogenesis of chronic inflammatory skin diseases. During psoriasis …
Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populations
JH Peters, GS Tjabringa, E Fasse, VL de Oliveira… - Journal of …, 2013 - Elsevier
BACKGROUND: Both keratinocytes and T-cells are crucial players in cutaneous immune
responses. We hypothesized that direct interactions between keratinocytes and T-cell …
responses. We hypothesized that direct interactions between keratinocytes and T-cell …
Taking the lead–how keratinocytes orchestrate skin T cell immunity
MM Klicznik, AB Szenes-Nagy, DJ Campbell, IK Gratz - Immunology letters, 2018 - Elsevier
The skin comprises a complex coordinated system of epithelial tissue cells and immune
cells that ensure adequate immune reactions against trauma, toxins and pathogens, while …
cells that ensure adequate immune reactions against trauma, toxins and pathogens, while …
Primary human keratinocytes efficiently induce IL‐1‐dependent IL‐17 in CCR6+ T cells
P Muhr, J Renne, V Schaefer, T Werfel… - Experimental …, 2010 - Wiley Online Library
Keratinocytes and activated T cells interact in skin inflammation by virtue of chemokines and
cytokines. T cell‐derived IL‐17 has been described to play an important role in the course of …
cytokines. T cell‐derived IL‐17 has been described to play an important role in the course of …
Th17 cells: a new paradigm for cutaneous inflammation
A Asarch, O Barak, DS Loo… - Journal of Dermatological …, 2008 - Taylor & Francis
Inflammatory processes of the skin have classically been segregated to either the cell‐
mediated, T‐helper type 1 (Th1) or the humoral (Th2) branch of the immune system. The …
mediated, T‐helper type 1 (Th1) or the humoral (Th2) branch of the immune system. The …
[HTML][HTML] Functions of Vγ4 T cells and dendritic epidermal T cells on skin wound healing
Y Li, J Wu, G Luo, W He - Frontiers in immunology, 2018 - frontiersin.org
Wound healing is a complex and dynamic process that progresses through the distinct
phases of hemostasis, inflammation, proliferation, and remodeling. Both inflammation and re …
phases of hemostasis, inflammation, proliferation, and remodeling. Both inflammation and re …
[HTML][HTML] A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis
IG Sérézal, E Hoffer, B Ignatov, E Martini, B Zitti… - Journal of Allergy and …, 2019 - Elsevier
Background Resident T cells are implicated in the maintenance and recurrence of psoriatic
lesions. Whether skin that has not yet experienced psoriasis in patients with established …
lesions. Whether skin that has not yet experienced psoriasis in patients with established …
Interleukin‐1 from epithelial cells fosters T cell‐dependent skin inflammation
J Renne, V Schäfer, T Werfel… - British Journal of …, 2010 - academic.oup.com
Background Chronic inflammatory skin diseases such as atopic dermatitis and psoriasis are
characterized by the infiltration of lymphocytes into the epidermal compartment. Several …
characterized by the infiltration of lymphocytes into the epidermal compartment. Several …
[HTML][HTML] Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis
EG Harper, C Guo, H Rizzo, JV Lillis, SE Kurtz… - Journal of Investigative …, 2009 - Elsevier
T helper (Th) 17 cells have recently been implicated in psoriasis pathogenesis, but
mechanisms of how these cells traffic into inflamed skin are unknown. By immunostaining for …
mechanisms of how these cells traffic into inflamed skin are unknown. By immunostaining for …
[HTML][HTML] Differential Capacity of Human Skin Dendritic Cells to Polarize CD4+T Cells into IL-17, IL-21 and IL-22 Producing Cells
K Penel-Sotirakis, E Simonazzi, J Peguet-Navarro… - PloS one, 2012 - journals.plos.org
Accumulating evidence suggests a contribution of T cell-derived IL-17, IL-21 and IL-22
cytokines in skin immune homeostasis as well as inflammatory disorders. Here, we analyzed …
cytokines in skin immune homeostasis as well as inflammatory disorders. Here, we analyzed …