The widespread occurrence of repetitive stretches of DNA in genomes of organisms across
the tree of life imposes fundamental challenges for sequencing, genome assembly, and …

Repetitive DNA sequences are abundant in a broad range of species, from bacteria to
mammals, and they cover nearly half of the human genome. Repeats have always …

The introduction of Next Generation Sequencing (NGS) technologies resulted in a major
transformation in the way scientists extract genetic information from biological systems …

Eukaryotic genome sequencing and de novo assembly, once the exclusive domain of well-
funded international consortia, have become increasingly affordable, thus fitting the budgets …

The RepeatsDB database (URL: https://repeatsdb. org/) provides annotations and
classification for protein tandem repeat structures from the Protein Data Bank (PDB). Protein …

Tandem repeat (TR) variation is associated with gene expression changes and numerous
rare monogenic diseases. Although long-read sequencing provides accurate full-length …

New DNA sequencing technologies can sequence up to one billion bases in a single day at
low cost, putting large-scale sequencing within the reach of many scientists. Many …

Background Genome sequencing yields the sequence of many short snippets of DNA
(reads) from a genome. Genome assembly attempts to reconstruct the original genome from …

Motivation: Repetitive DNA makes up large portions of plant and animal nuclear genomes,
yet it remains the least-characterized genome component in most species studied so far …

Abstract Background The first Atlantic cod (Gadus morhua) genome assembly published in
2011 was one of the early genome assemblies exclusively based on high-throughput 454 …