The kidney is the organ responsible for the regulation of the body's fluid balance.
Hyaluronan (HA), because of its unique hydration capacity, is used dynamically by the …

The glycosaminoglycan (GAG) hyaluronan (HA) is recognized as an important structural
component of the extracellular matrix, but it also interacts with cells during embryonic …

Over the years, hyaluronic acid (HA) has emerged as an important molecule in
nephrological and urological studies involving extracellular matrix (ECM) organization …

Over the years, hyaluronic acid (HA) has become an important molecule in nephrology and
urology studies involving extracellular matrix (ECM) organization, inflammation, tissue …

Hyaluronan (HA) is a negatively charged extracellular matrix (ECM) component with water-
attracting properties. It is the dominating ECM component in the renal medullary interstitium …

Hyaluronan is apically secreted and expressed by proliferating or regenerating renal tubular
cells. Background Hyaluronan has diverse biologic functions in the body, varying from …

In the healthy kidney, hyaluronan (HA) is present at high concentration in the medullary
interstitium and at very low concentration in the cortex. Using various rat models, we have …

Background The stroma plays a key role during renal development and in regeneration after
injury. However, following injury, the stroma expands driving progressive fibrosis …

The functional consequences of increased renal cortical hyaluronan that is associated with
both acute injury and progressive scarring are unclear. The aim of this study was to …

Methods We conducted ex vivo and in vivo experiments to explore the effects of degrading
glomerular hyaluronan by administering hyaluronidase and of supplementation with …