The current landscape of early drug development for patients with sarcoma

BA Wilky, RL Jones, VL Keedy - American Society of Clinical …, 2017 - ascopubs.org
Until recently, advancements in the treatment of patients with adult soft tissue sarcomas
have been relatively slow. This is, in part, due to their heterogeneity and rarity. A better …

Contemporary therapy for advanced soft-tissue sarcomas in adults: a review

A Pang, M Carbini, RG Maki - JAMA oncology, 2016 - jamanetwork.com
Importance Immune checkpoint inhibitors have shown promising results in several cancers
and are now put to the test in sarcomas. This brief summary presents data regarding the …

Targeted therapy and promising novel agents for the treatment of advanced soft tissue sarcomas

N Mohindra, M Agulnik - Expert opinion on investigational drugs, 2015 - Taylor & Francis
Introduction: Soft tissue sarcomas (STS) are a rare and difficult to treat malignancy. Efforts to
utilize targeted therapy have been ongoing for the last decade and have resulted in the …

[HTML][HTML] Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting

J Yang, Y Xu, Y Chen, T Li, X Zhang, T Hu… - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
At the recent 2022 American Society of Clinical Oncology (ASCO) annual meeting, the latest
progress was presented in clinical trials of various therapeutic modalities for adult soft tissue …

Targeted agents for sarcoma: is individualized therapy possible in such a diverse tumor type?

RF Riedel - Seminars in oncology, 2011 - Elsevier
A wide variety of cytogenetic abnormalities and molecular pathways have been implicated in
the pathogenesis of sarcoma, and significant progress has been made in the past decade …

The past, present, and future of cytotoxic chemotherapy and pathway-directed targeted agents for soft tissue sarcoma

CW Ryan, J Desai - … Society of Clinical Oncology Educational Book, 2013 - ascopubs.org
The individual rarity of the many subtypes of soft tissue sarcomas has historically mandated
an empiric approach to systemic therapy. Doxorubicin, first reported to have activity in …

The current reality of soft tissue sarcomas: advances, controversies, areas for improvement, and promising new treatments

JY Blay, A Le Cesne, GD Demetri - Expert Review of Anticancer …, 2020 - Taylor & Francis
Introduction: Soft tissue sarcomas (STS) encompass a group of rare and heterogeneous
cancers. Rapid evolution in the field justifies a focused critical review of the clinical literature …

New therapeutics for soft-tissue sarcomas in adults.

M von Mehren - Oncology, 2007 - go.gale.com
Soft-tissue sarcomas are an uncommon set of malignancies that pose a therapeutic
challenge. Representing a mixture of multiple histologies, approximately 9,000 cases were …

Treatment of adult soft tissue sarcoma: old concepts, new insights, and potential for drug discovery

JB Aragon-Ching, RG Maki - Cancer investigation, 2012 - Taylor & Francis
Soft tissue sarcomas are a heterogeneous group of mesenchymal tumors that vary in their
behavior as well as treatment. Certain histologic subtypes predict for response to particular …

Using single-agent therapy in adult patients with advanced soft tissue sarcoma can still be considered standard care

S Sleijfer, C Seynaeve, J Verweij - The oncologist, 2005 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
the current status of the chemotherapeutic treatment of advanced soft tissue sarcomas in …