The current landscape of early drug development for patients with sarcoma
Until recently, advancements in the treatment of patients with adult soft tissue sarcomas
have been relatively slow. This is, in part, due to their heterogeneity and rarity. A better …
have been relatively slow. This is, in part, due to their heterogeneity and rarity. A better …
Contemporary therapy for advanced soft-tissue sarcomas in adults: a review
A Pang, M Carbini, RG Maki - JAMA oncology, 2016 - jamanetwork.com
Importance Immune checkpoint inhibitors have shown promising results in several cancers
and are now put to the test in sarcomas. This brief summary presents data regarding the …
and are now put to the test in sarcomas. This brief summary presents data regarding the …
Targeted therapy and promising novel agents for the treatment of advanced soft tissue sarcomas
N Mohindra, M Agulnik - Expert opinion on investigational drugs, 2015 - Taylor & Francis
Introduction: Soft tissue sarcomas (STS) are a rare and difficult to treat malignancy. Efforts to
utilize targeted therapy have been ongoing for the last decade and have resulted in the …
utilize targeted therapy have been ongoing for the last decade and have resulted in the …
[HTML][HTML] Therapeutic perspectives for adult soft tissue sarcoma—updates from the 2022 ASCO annual meeting
J Yang, Y Xu, Y Chen, T Li, X Zhang, T Hu… - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
At the recent 2022 American Society of Clinical Oncology (ASCO) annual meeting, the latest
progress was presented in clinical trials of various therapeutic modalities for adult soft tissue …
progress was presented in clinical trials of various therapeutic modalities for adult soft tissue …
Targeted agents for sarcoma: is individualized therapy possible in such a diverse tumor type?
RF Riedel - Seminars in oncology, 2011 - Elsevier
A wide variety of cytogenetic abnormalities and molecular pathways have been implicated in
the pathogenesis of sarcoma, and significant progress has been made in the past decade …
the pathogenesis of sarcoma, and significant progress has been made in the past decade …
The past, present, and future of cytotoxic chemotherapy and pathway-directed targeted agents for soft tissue sarcoma
The individual rarity of the many subtypes of soft tissue sarcomas has historically mandated
an empiric approach to systemic therapy. Doxorubicin, first reported to have activity in …
an empiric approach to systemic therapy. Doxorubicin, first reported to have activity in …
The current reality of soft tissue sarcomas: advances, controversies, areas for improvement, and promising new treatments
JY Blay, A Le Cesne, GD Demetri - Expert Review of Anticancer …, 2020 - Taylor & Francis
Introduction: Soft tissue sarcomas (STS) encompass a group of rare and heterogeneous
cancers. Rapid evolution in the field justifies a focused critical review of the clinical literature …
cancers. Rapid evolution in the field justifies a focused critical review of the clinical literature …
New therapeutics for soft-tissue sarcomas in adults.
M von Mehren - Oncology, 2007 - go.gale.com
Soft-tissue sarcomas are an uncommon set of malignancies that pose a therapeutic
challenge. Representing a mixture of multiple histologies, approximately 9,000 cases were …
challenge. Representing a mixture of multiple histologies, approximately 9,000 cases were …
Treatment of adult soft tissue sarcoma: old concepts, new insights, and potential for drug discovery
JB Aragon-Ching, RG Maki - Cancer investigation, 2012 - Taylor & Francis
Soft tissue sarcomas are a heterogeneous group of mesenchymal tumors that vary in their
behavior as well as treatment. Certain histologic subtypes predict for response to particular …
behavior as well as treatment. Certain histologic subtypes predict for response to particular …
Using single-agent therapy in adult patients with advanced soft tissue sarcoma can still be considered standard care
S Sleijfer, C Seynaeve, J Verweij - The oncologist, 2005 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to: Discuss
the current status of the chemotherapeutic treatment of advanced soft tissue sarcomas in …
the current status of the chemotherapeutic treatment of advanced soft tissue sarcomas in …