Advancing Alzheimer's therapeutics: Exploring the impact of physical exercise in animal models and patients

J Andrade-Guerrero, P Rodríguez-Arellano… - Cells, 2023 - mdpi.com
Alzheimer's disease (AD) is the main neurodegenerative disorder characterized by several
pathophysiological features, including the misfolding of the tau protein and the amyloid beta …

Exercise Intervention for Alzheimer's Disease: Unraveling Neurobiological Mechanisms and Assessing Effects

J Ren, H Xiao - Life, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease and a major cause of
age-related dementia, characterized by cognitive dysfunction and memory impairment. The …

Physical exercise protocols in animal models of Alzheimer's disease: a systematic review

RAL De Sousa, CM Rodrigues, BF Mendes… - Metabolic Brain …, 2021 - Springer
Several animal studies have showed the beneficial effects of physical exercise (PE) on brain
function and health. Alzheimer's Disease (AD) is the most common type of dementia …

[HTML][HTML] Can exercise training teach us how to treat Alzheimer's disease?

AM Huuha, CS Norevik, JBN Moreira… - Ageing research …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and there is currently no
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …

Early-stage Alzheimer's disease: are skeletal muscle and exercise the key?

MH Brisendine, JC Drake - Journal of Applied Physiology, 2023 - journals.physiology.org
Alzheimer's disease (AD) is the most common form of dementia affecting approximately 6.5
million people in the United States alone. The development of AD progresses over a span of …

Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease

SM Ryan, ÁM Kelly - Ageing research reviews, 2016 - Elsevier
It is now well established, at least in animal models, that exercise elicits potent pro-cognitive
and pro-neurogenic effects. Alzheimer's disease (AD) is one of the leading causes of …

Understanding how physical exercise improves Alzheimer's disease: cholinergic and monoaminergic systems

B Zong, F Yu, X Zhang, W Zhao, P Sun… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is an age-related neurodegenerative disorder, characterized by
the accumulation of proteinaceous aggregates and neurofibrillary lesions composed of β …

Relationship between exercise and Alzheimer's disease: a narrative literature review

Q Meng, MS Lin, IS Tzeng - Frontiers in neuroscience, 2020 - frontiersin.org
This narrative review aimed to summarize evidence regarding the responses to exercise
among patients with preclinical Alzheimer's disease (AD) and the effectiveness of long-term …

Exercise plays a preventive role against Alzheimer's disease

Z Radak, N Hart, L Sarga, E Koltai… - Journal of …, 2010 - content.iospress.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly
population. It is predicted that the incidence of AD will be increased in the future making this …

[HTML][HTML] Beneficial effects of exercise pretreatment in a sporadic Alzheimer's rat model

C Wu, L Yang, D Tucker, YAN Dong, L Zhu… - Medicine and science …, 2018 - ncbi.nlm.nih.gov
PURPOSE This study aimed to examine the effects of swimming exercise pretreatment on a
streptozotocin (STZ)-induced sporadic Alzheimer's disease rat model and provide an initial …