IS26 and the IS26 family: versatile resistance gene movers and genome reorganizers
In Gram-negative bacteria, the insertion sequence IS 26 is highly active in disseminating
antibiotic resistance genes. IS 26 can recruit a gene or group of genes into the mobile gene …
antibiotic resistance genes. IS 26 can recruit a gene or group of genes into the mobile gene …
Movement of IS 26-associated antibiotic resistance genes occurs via a translocatable unit that includes a single IS 26 and preferentially inserts adjacent to another IS …
The insertion sequence IS 26 plays a key role in disseminating antibiotic resistance genes in
Gram-negative bacteria, forming regions containing more than one antibiotic resistance …
Gram-negative bacteria, forming regions containing more than one antibiotic resistance …
IS26 Family Members IS257 and IS1216 Also Form Cointegrates by Copy-In and Targeted Conservative Routes
ABSTRACT IS 26 has been shown to form cointegrates both by a copy-in mechanism
involving one insertion sequence (IS) and a target and by a targeted conservative …
involving one insertion sequence (IS) and a target and by a targeted conservative …
IS26-Mediated Formation of Transposons Carrying Antibiotic Resistance Genes
ABSTRACT The IS 26 transposase, Tnp26, catalyzes IS 26 movement to a new site and
deletion or inversion of adjacent DNA via a replicative route. The intramolecular deletion …
deletion or inversion of adjacent DNA via a replicative route. The intramolecular deletion …
An IS26 variant with enhanced activity
The insertion sequence IS 26 plays a major role in the mobilization, expression and
dissemination of antibiotic resistance genes in Gram-negative bacteria. Though IS 26 is …
dissemination of antibiotic resistance genes in Gram-negative bacteria. Though IS 26 is …
The IS6 family, a clinically important group of insertion sequences including IS26
The IS 6 family of bacterial and archaeal insertion sequences, first identified in the early
1980s, has proved to be instrumental in the rearrangement and spread of multiple antibiotic …
1980s, has proved to be instrumental in the rearrangement and spread of multiple antibiotic …
The IS 200/IS605 Family and “Peel and Paste” Single‐strand Transposition Mechanism
Members of the widespread IS200/IS605bacterial insertion sequence (IS) family transpose
using obligatory single‐strand (ss) DNA intermediates. This distinguishes them from …
using obligatory single‐strand (ss) DNA intermediates. This distinguishes them from …
Targeted Conservative Cointegrate Formation Mediated by IS26 Family Members Requires Sequence Identity at the Reacting End
ABSTRACT IS 26 forms cointegrates using two distinct routes, a copy-in mechanism
involving one insertion sequence (IS) and a target and a targeted conservative mechanism …
involving one insertion sequence (IS) and a target and a targeted conservative mechanism …
[HTML][HTML] The new IS1595 family, its relation to IS1 and the frontier between insertion sequences and transposons
A picture of insertion sequence (IS) diversity is emerging in which previously well-defined
groups or families, while remaining tightly clustered, no longer have defined borders but …
groups or families, while remaining tightly clustered, no longer have defined borders but …
Structures bounded by directly-oriented members of the IS26 family are pseudo-compound transposons.
Antibiotic resistance genes are often found in structures bounded by copies of IS26,
IS257/IS431 or IS1216 that resemble compound (or composite) transposons. However …
IS257/IS431 or IS1216 that resemble compound (or composite) transposons. However …