Part of the broader glycosphingolipid family, gangliosides are composed of a ceramide
bound to a sialic acid-containing glycan chain, and locate at the plasma membrane …

Gangliosides are carbohydrate-containing sphingolipids that are widely expressed in
normal tissues, making most subtypes unsuitable as targets for cancer therapy. However …

Introduction: Ganglioside GD2 is found in vertebrates and invertebrates, overexpressed
among pediatric and adult solid tumors, including neuroblastoma, glioma, retinoblastoma …

Disialoganglioside GD2 is a promising target for immunotherapy with expression primarily
restricted to neuroectodermal and epithelial tumor cells. Although its role in the maintenance …

Gangliosides are a large subfamily of glycosphingolipids that broadly exist in the nervous
system and interact with signaling molecules in the lipid rafts. GD3 and GD2 are two types of …

Target selection is a key feature in cancer immunotherapy, a promising field in cancer
research. In this respect, gangliosides, a broad family of structurally related glycolipids, were …

At the outer leaflet of the plasma membrane, gangliosides are found with other
glycosphingolipids, phospholipids, and cholesterol in glycolipid-enriched microdomains, in …

Background Ganglioside GD2 is expressed on plasma membranes of various types of
malignant cells. One of the most promising approaches for cancer immunotherapy is the …

Aberrant expression of glycosphingolipids is a hallmark of cancer cells and is associated
with their malignant properties. Disialylated gangliosides GD2 and GD3 are considered as …

Ganglioside GD2 is a plasma membrane glycosphinogolipid. In healthy adults it is
expressed at low levels, but it is over-expressed in many cancers. For cancer therapy, GD2 …