The voltage-gated potassium channel KV10. 1 is a member of the ether-à-go-go family,
which also includes the erg (eag-related gene, KV11) and elk (eag-like K+ channel, KV12) …

Carcinogenesis is a multistage process involving the dysregulation of multiple genes,
proteins, and pathways that make any normal cell acquire a cancer cell phenotype …

Voltage-gated potassium channel Kv1. 3 is an integral membrane protein, which is
selectively permeable for potassium ions and is activated upon a change of membrane …

Membrane ion channels participate in cancerous processes such as proliferation, migration
and invasion, which contribute to metastasis. Increasing evidence indicates that voltage …

Abstract Background Kv10. 1, a voltage-gated potassium channel only detected in the
healthy brain, was found to be aberrantly expressed in extracerebral cancers. Investigations …

Potassium channels (KCh) are a diverse group of membrane proteins that participate in the
control of the membrane potential. More than eighty different KCh genes have been …

The KCNH1 gene encodes the Kv10. 1 (Eag1) ion channel, a member of the EAG (ether-à-
go-go) family of voltage-gated potassium channels. Recent studies have demonstrated that …

Background Ion channels have been proposed as therapeutic targets for different types of
malignancies. One of the most studied ion channels in cancer is the voltage-gated …

Deregulation of voltage-gated potassium channel subunit Kv1. 3 has been reported in many
tumors. Kv1. 3 promotes tumorigenesis by enhancing cell proliferation while suppressing …

Voltage-dependent potassium (Kv) channels contribute to the excitability of nerves and
muscles. In addition, Kv participates in several cell functions, including cell cycle …