Ankylosing spondylitis (AS) is a common, highly heritable arthropathy, the pathogenesis of
which is poorly understood. The mechanism by which the main gene for the disease, HLA …

The increasing list of genes identified as being definitely involved in AS provides a useful
platform for hypothesis-driven research in the field, providing a potential alternative route to …

Ankylosing spondylitis (AS) is a chronic inflammatory disease of unknown etiology, though it
is considered an autoimmune disease. HLA‐B27 is the risk factor most often associated with …

There is substantial evidence strongly favouring a direct role for HLA-B27 in genetic
susceptibility to ankylosing spondylitis (AS) and related spondyloarthropathies (SpA) …

Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease, characterized by
typically an axial arthritis. AS is the prototype of a group of disorders called …

Over the past 5 years, advances in high-throughput techniques and studies involving large
cohorts of patients have led to considerable advances in the identification of novel genetic …

Ankylosing spondylitis (AS), an immune-mediated arthritis, is the prototypic member of a
group of conditions known as spondyloarthropathies that also includes reactive arthritis …

With the mapping of the human genome having been completed, our ability to investigate
and ideally better understand the genetic basis of rheumatic diseases is advancing at a …

Ankylosing spondylitis is a highly heritable, common rheumatic condition, primarily affecting
the axial skeleton. The association with HLA-B27 has been demonstrated worldwide, and …

The association of HLA-B27 with ankylosing spondylitis (AS) remains as one of the
intriguing models that could exist between a molecule and human disease in medicine …