Over the past decade, genome-wide association studies (GWAS) have considerably
improved our understanding of the genetic basis of kidney function and disease. Population …

Chronic kidney disease (CKD) is common, affecting about 10% of the general population,
and causing significant morbidity and mortality. Apart from the risk conferred by traditional …

Kidney diseases constitute a serious public health burden worldwide, with substantial
associated morbidity and mortality. The role of a genetic contribution to kidney disease is …

The past few years have seen major advances in genome-wide association studies (GWAS)
of CKD and kidney function–related traits in several areas: increases in sample size from> …

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

Genome-wide association studies (GWAS) have identified hundreds of loci associated with
kidney-related traits such as glomerular filtration rate, albuminuria, hypertension, electrolyte …

With increasing incidence and a prev-alence of> 10% among adults worldwide, chronic
kidney disease (CKD) represents a major public health issue. 1 CKD can lead to metabolic …

The past 3 years have witnessed a dramatic expansion in our knowledge of the genetic
determinants of estimated glomerular filtration rate (eGFR) and chronic kidney disease …

In conducting genome-wide association studies (GWAS), analytical approaches leveraging
biological information may further understanding of the pathophysiology of clinical traits. To …

Genome-wide association studies (GWAS) have identified> 100 loci of chronic kidney
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …