Objective To determine the effectiveness and safety of moderate whole-body hypothermia in
newborns with hypoxic-ischemic encephalopathy born in hospitals with and without …

BACKGROUND. Whole-body hypothermia reduced the frequency of death or
moderate/severe disabilities in neonates with hypoxic-ischemic encephalopathy in a …

Importance Hypothermia initiated at less than 6 hours after birth reduces death or disability
for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our …

Objectives To systematically review the effectiveness, as determined by survival without
moderate to severe neurodevelopmental disability in infancy and childhood, and the safety …

OBJECTIVE: To examine the predictive ability of stage of hypoxic-ischemic encephalopathy
(HIE) for death or moderate/severe disability at 18 months among neonates undergoing …

Hypoxic ischemic encephalopathy (HIE) remains a significant cause of mortality and long-
term disability in late preterm and term infants. Mild therapeutic hypothermia to a rectal …

Objective To evaluate the safety and short-term outcomes of preterm neonates born at 34-35
weeks gestation with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic …

Background Hypothermia is protective against brain injury after asphyxiation in animal
models. However, the safety and effectiveness of hypothermia in term infants with …

Background We previously reported early results of a randomized trial of whole-body
hypothermia for neonatal hypoxic–ischemic encephalopathy showing a significant reduction …

Therapeutic hypothermia holds promise as a rescue neuroprotective strategy for hypoxic-
ischemic injury, but the incidence of severe neurologic sequelae with hypothermia is …