Conventional assays for quantifying the virulence of microbial pathogens and mutants have
traditionally relied upon the use of a range of mammalian species. A number of workers …

The study of human diseases requires the testing of microorganisms in model systems.
Although mammals are typically used, we argue the validity of using insects as models in …

Insects are convenient models for assessing the virulence of microbial pathogens or for
assessing the efficacy of antimicrobial drugs and give results comparable to those that can …

The study of bacterial virulence often requires a suitable animal model. Mammalian models
of infection are costly and may raise ethical issues. The use of insects as infection models …

The immune response of insects displays many structural and functional similarities to the
innate immune response of mammals. As a result of these conserved features, insects may …

The immune system of insects and the innate immune response of mammals share many
similarities and, as a result, insects may be used to assess the virulence of fungal pathogens …

The use of invertebrate model hosts has increased in popularity due to numerous
advantages of invertebrates over mammalian models, including ethical, logistical and …

As a result of the strong structural and functional similarities between the innate immune
system of mammals and the insect immune response, insects have been exploited for …

abstract Galleria mellonella (greater wax moth or honeycomb moth) has been introduced as
an alternative model to study microbial infections. G. mellonella larvae can be easily and …

The morbidity, mortality and economic burden associated with fungal infections, together
with the emergence of fungal strains resistant to current antimicrobial agents, necessitate …