Alcohol aggravates ketamine-induced behavioral, morphological and neurochemical alterations in adolescent rats: The involvement of CREB-related pathways

D Zuo, Y Liu, Z Liu, J Cui, X Zhou, Y Liu, Z Li… - Behavioural Brain …, 2018 - Elsevier
Currently, an increasing proportion of adolescent ketamine users simultaneously consume
alcohol. However, the potential behavioural and neurological alterations induced by such a …

The effects of sub-anesthetic ketamine plus ethanol on behaviors and apoptosis in the prefrontal cortex and hippocampus of adolescent rats

Q Li, H Wu, S Fan, D Liu, H Jiang, Q Zhang… - Pharmacology …, 2019 - Elsevier
Ketamine has become increasingly popular in adolescent drug abusers worldwide.
Meanwhile, alcohol is usually used by ketamine users. However, little work has been …

The interactive effects of ketamine and ethanol on dopamine expression in the ventral tegmental area of rats

ZB Zhang, TY Xu, DY You, S Yi, Q Liu… - Neuropsychiatric …, 2018 - Taylor & Francis
Background A number of studies have demonstrated the significant and rapid
antidepressant effects of ketamine, which is also known as a neurotoxic and illicit drug …

[HTML][HTML] Alcohol amplifies ketamine-induced apoptosis in primary cultured cortical neurons and PC12 cells through down-regulating CREB-related signaling pathways

D Zuo, F Sun, J Cui, Y Liu, Z Liu, X Zhou, Z Li, Y Wu - Scientific Reports, 2017 - nature.com
Recreational use of ketamine (KET) has been increasing worldwide. Previous studies have
demonstrated that KET induced neurotoxicity; however, few studies have examined how …

[HTML][HTML] One binge-type cycle of alcohol plus ketamine exposure induces emotional-like disorders associated with oxidative damage in adolescent female rats

CCM da Silveira, S de Carvalho Cartágenes… - Biomedicine & …, 2023 - Elsevier
Drug abuse is a global public health problem among adolescents, with alcohol often used in
association with other psychotropic drugs, such as ketamine. Considering the scarcity of …

Subchronic ketamine alters behaviour, metabolic indices and brain morphology in adolescent rats: Involvement of oxidative stress, glutamate toxicity and caspase-3 …

AY Onaolapo, OJ Ayeni, MO Ogundeji, A Ajao… - Journal of chemical …, 2019 - Elsevier
Ketamine is a dissociative anaesthetic agent whose recreational use amongst adolescents
and young adults is reaching epidemic proportions in a number of countries. While animal …

Ketamine exposure in adult mice leads to increased cell death in C3H, DBA2 and FVB inbred mouse strains

CR Majewski-Tiedeken, CR Rabin, SJ Siegel - Drug and alcohol …, 2008 - Elsevier
BACKGROUND: Drug abuse is common among adolescents and young adults. Although
the consequences of intoxication are known, sequelae of drugs emerging on campuses and …

Juvenile exposure to ketamine causes delayed emergence of EEG abnormalities during adulthood in mice

RE Featherstone, LR Nagy, CG Hahn… - Drug and alcohol …, 2014 - Elsevier
Background Increased susceptibility to cognitive impairment or psychosis in adulthood is
associated with adolescent drug abuse. Studies in adults have identified impairments in …

[HTML][HTML] Neuropsychological Assessment of Learning and Memory in Rats Following Ketamine Exposure during Late Adolescence

JM Davis, D Compton, M Heit, A Fravel… - Journal of Behavioral and …, 2020 - scirp.org
With the prevalent issue of drug abuse in society, research regarding the effects of ketamine,
a drug frequently abused by youth in club settings, has increased. Despite its potential for …

Chronic ketamine exposure induces permanent impairment of brain functions in adolescent cynomolgus monkeys

L Sun, Q Li, Q Li, Y Zhang, D Liu, H Jiang… - Addiction …, 2014 - Wiley Online Library
Ketamine, a non‐competitive N‐methyl‐D‐aspartic acid receptor antagonist, has emerged
as an increasingly popular drug among young drug abusers worldwide. Available evidence …