In antigen‐presenting cells (APCs), loading of major histocompatibility complex class II
(MHC II) molecules with peptides is regulated by invariant chain (Ii), which blocks MHC II …

In B cells, the non‐classical human leukocyte antigens HLA‐DO (DO) and HLA‐DM (DM)
are residents of lysosome‐like organelles where they form tight complexes. DM catalyzes …

MHC class II (MHC-II) molecules are critical in the control of many immune responses. They
are also involved in most autoimmune diseases and other pathologies. Here, we describe …

Peptide binding to classical major histocompatibility complex (MHC) class II molecules is
known to be determined by the properties of the class ii peptide binding groove but recently …

HLA-DM catalyzes the exchange and selection of ligands for MHC class II molecules within
mature endosomal/lysosomal compartments. Here, evidence is provided that DM edits …

The nonclassical major histocompatibility complex of class II molecules (ncMHCII) HLA‐DM
(DM) and HLA‐DO (DO) feature essential functions for the selection of the peptides that are …

HLA-DM serves a critical function in the loading and editing of peptides on MHC class II
(MHCII) molecules. Recent data showed that the interaction cycle between MHCII molecules …

In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in
several mouse and human haplotypes has increased our understanding of the molecular …

Loading of classical major histocompatibility complex (MHC) class II molecules with antigen-
derived peptides is fast, efficient and highly selective in vivo, quite in contrast to in vitro …

Highlights•MHC-I molecules exhibit allotype-dependent conformational flexibility, which is
critical for their function.•Peptide-deficient MHC-I adopt distinct groove conformations …