Regulation of gene expression drives protein interactions that govern synaptic wiring and
neuronal activity. The resulting coordinated activity among neuronal populations supports …

Understanding human-specific patterns of brain gene expression and regulation can
provide key insights into human brain evolution and speciation. Here, we use next …

The human brain is comprised of a complex web of functional networks that link
anatomically distinct regions. However, the biological mechanisms supporting network …

Gene networks have yielded numerous neurobiological insights, yet an integrated view
across brain regions is lacking. We leverage RNA sequencing in 864 samples representing …

Given the tremendous complexity of brain organisation, here I propose a strategy that
dynamically links stages of brain organisation from genes to consciousness, at four …

Enhanced cognitive function in humans is hypothesized to result from cortical expansion
and increased cellular diversity. However, the mechanisms that drive these phenotypic …

Our understanding of the evolution, formation, and pathological disruption of human brain
circuits is impeded by a lack of comprehensive data on the developing brain transcriptome …

In the mammalian cortex, neurons and glia form a patterned structure across six layers
whose complex cytoarchitectonic arrangement is likely to contribute to cognition. We …

How does the organization of neural information processing enable humans' sophisticated
cognition? Here we decompose functional interactions between brain regions into …

Genetic determinants of cognition are poorly characterized, and their relationship to genes
that confer risk for neurodevelopmental disease is unclear. Here we performed a systems …