HIV infection, inflammation, immunosenescence, and aging

SG Deeks - Annual review of medicine, 2011 - annualreviews.org
Although antiretroviral therapy for HIV infection prevents AIDS-related complications and
prolongs life, it does not fully restore health. Long-term treated patients remain at higher than …

[HTML][HTML] Aging, inflammation, and HIV infection

JA Aberg - Topics in antiviral medicine, 2012 - ncbi.nlm.nih.gov
Prolonged survival in HIV infection is accompanied by an increased frequency of non-HIV-
related comorbidities. A number of age-related comorbidities occur earlier in HIV-infected …

HIV as a cause of immune activation and immunosenescence

T Sokoya, HC Steel, M Nieuwoudt… - Mediators of …, 2017 - Wiley Online Library
Systemic immune activation has emerged as an essential component of the
immunopathogenesis of HIV. It not only leads to faster disease progression, but also to …

Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy.

SG Deeks - Topics in HIV medicine: a publication of the …, 2009 - europepmc.org
Patients receiving long-term antiretroviral therapy are at increased risk of age-associated
non-AIDS-related morbidity and mortality compared with HIV-seronegative persons. Despite …

Immunosenescence and HIV

SG Deeks, E Verdin, JM McCune - Current opinion in immunology, 2012 - Elsevier
PURPOSE OF REVIEW: The present review discusses the interplay between HIV infection
and other environmental factors (eg co-infection with CMV) in the acceleration of the aging …

Immune activation and immune aging in HIV infection

V Appay, AD Kelleher - Current Opinion in HIV and AIDS, 2016 - journals.lww.com
Our understanding of the precise link between immune activation and aging in HIV infection
is complicated by the influence of coinfections and life style factors. Developing rational …

Early immune senescence in HIV disease

S Desai, A Landay - Current HIV/AIDS Reports, 2010 - Springer
Non-AIDS-defining co-morbidities that occur despite viral suppression and immune
reconstitution using antiretroviral therapy depict early aging process in HIV-infected …

[HTML][HTML] HIV and aging

EJ Wing - International journal of infectious diseases, 2016 - Elsevier
With the wider availability of antiretrovirals, the world's HIV population is aging. More than
10% of the 34.5 million HIV-positive individuals worldwide are over the age of 50 years and …

Ageing and inflammation in patients with HIV infection

M Nasi, S De Biasi, L Gibellini… - Clinical & …, 2017 - academic.oup.com
Nowadays, HIV+ patients have an expected lifespan that is only slightly shorter than healthy
individuals. For this reason, along with the fact that infection can be acquired at a relatively …

HIV and aging: state of knowledge and areas of critical need for research. A report to the NIH Office of AIDS Research by the HIV and Aging Working Group

KP High, M Brennan-Ing, DB Clifford… - JAIDS Journal of …, 2012 - journals.lww.com
HIV risk behaviors, susceptibility to HIV acquisition, progression of disease after infection,
and response to antiretroviral therapy all vary by age. In those living with HIV, current …