Pediatric Clinical Pharmacology of Digoxin Page 1 Symposium on Progress in Drug Therapy
for Children Pediatric Clinical Pharmacology of Digoxin Lester F. Soyka, MD* The purpose of …

Although digoxin is invaluable for a variety of cardiovascular diseases, and it is virtually the
only cardiac glycoside in common use today in children and infants, it is known to have a …

The foregoing discussion leads to several general conclusions regarding the use of digoxin
in the pediatric patient. First, pharmacokinetic studies indicate that somewhat higher doses …

Information is presented concerning advances in the management of heart failure, digitalis
dosage in infancy, and interpretation of results of serum radioimmunoassay for the diagnosis …

The pharmacokinetic properties and dosage guidelines for digoxin in pediatric patients with
congestive heart failure are reviewed. Interindividual variability in the pharmacokinetics of …

Digoxin is suggested as the drug of choice for digitalis therapy in infants and children,
primarily because of its rapid dissipation. The use of average dosage figures, while …

The distribution of digoxin in the myocardium, skeletal muscle, erythrocytes, and plasma (or
serum) was studied in 19 infants. There was a linear relationship between myocardium and …

The pharmacokinetics and pharmacodynamics of digoxin in premature infants was studied.
Duringmaintenance therapy, after a total digitalizing dose of 30 μg/kg, the measured digoxin …

Abstract Between January 1981 and April 1984, excessive serum concentrations of digoxin
(5 ng/ml or higher) were recorded in 47 children, aged 2 days to 16 years. In 10 patients, the …

During childhood digitalis glycosides are most frequently used during the newborn period.
Within two years, we found evidence of digoxin intoxication in eight newborns. This was …