The cytochrome P450, family 2, subfamily C, polypeptide 19 (CYP2C19) gene is located
within a cluster of cytochrome P450 genes (centromere-CYP2C18-CYP2C19-CYP2C9 …

Cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8) is a phase I metabolizing
enzyme that plays an integral role in the biotransformation of structurally diverse xenobiotics …

Human cytochrome P-450 (CYP-450), family 2, subfamily A, polypeptide 6 (CYP2A6) is a
monooxygenase enzyme that metabolizes xenobiotic compounds and activates toxins [1–3] …

CYP2B6 is a member of the cytochrome P450 family of important pharmacogenes and
makes up approximately 2–10% of the total hepatic CYP content [1]. CYP2B6 is also …

CYP2C9 is a phase I drug-metabolizing cytochrome P450 (CYP450) enzyme isoform that
plays a major role in the oxidation of both xenobiotic and endogenous compounds. Gray et …

The aim of a PharmGKB VIP summary is to provide a simple overview of a gene with respect
to drug effects. In some cases, there may be extensive evidence of variants that have known …

Background CYP1A2 is part of the cytochrome P450 (CYP) family of drug-metabolizing
enzymes. The CYP1A2 gene is found in a cluster with CYP1A1 and CYP1B1 on …

Human cytochrome P450 2C9 (CYP2C9) accounts for∼ 20% of total hepatic CYP content
and metabolizes∼ 15% clinically used drugs including S-warfarin, tolbutamide, phenytoin …

CYP2C9 and CYP2C19 are important drug metabolizing enzymes and together metabolize
about 18% of currently available drugs. Some of the important groups of drugs that are …

Cytochrome P450 (CYP) 2C8 is responsible for the oxidative metabolism of many clinically
available drugs from a diverse number of drug classes (eg, thiazolidinediones, meglitinides …