Identification of the genes involved in prostate cancer (PCa) progression to a virulent and
androgen-independent (AI) form is a major focus in the field. cDNA microarray was used to …

Because of the heterogeneous nature of prostate cancer, identifying the molecular
mechanisms involved during the transition from an androgen-sensitive to an androgen …

The LNCaP/C4‐2 human prostate cancer progression model was established to mimic
phenotypic and genotypic changes during prostate cancer development from androgen …

Previously, we have developed a unique in vitro LNCaP cell model, which includes
androgen-dependent (LNCaP-C33), androgen-independent (LNCaP-C81) and an …

Lethal phenotypes of human prostate cancer are characterized by progression to androgen‐
independence and metastasis. For want of a clinically relevant animal model, mechanisms …

BACKGROUND A major focus of prostate cancer research has been to identify genes that
are deregulated during tumor progression, potentially providing diagnostic markers and …

Prostate cancer tends to become transformed to androgen-independent disease over time
when treated by androgen-deprivation therapy. We used two variants of the human prostate …

BACKGROUND Clinically, the lethal phenotypes of human prostate cancer are
characterized by their progression to androgen‐independence and their propensity to form …

Studies on the genetic basis of prostate cancer (PCa) have lead to mixed results with the
only consensus being that PCa is a complex disease. Our goal was to gain insight into …

BACKGROUND Prostate carcinoma progression from an androgen dependent (AD) state to
an androgen independent (AI) state occurs clinically in patients who undergo hormonal …