High‐grade vulvar intraepithelial neoplasia: comprehensive characterization and long‐term vulvar carcinoma risk

NB Thuijs, M van Beurden, S Duin… - …, 2024 - Wiley Online Library
Aims Adequate diagnosis of human papillomavirus (HPV)‐associated high‐grade
squamous intraepithelial lesion (HSIL) and HPV‐independent vulvar intraepithelial …

Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma

M Del Pino, L Rodriguez‐Carunchio, J Ordi - Histopathology, 2013 - Wiley Online Library
Vulvar squamous cell carcinoma (VSCC) accounts for> 90% of the malignant tumours of the
vulva. Most VSCC s originate in intraepithelial lesions, named vulvar intraepithelial …

Vulvar squamous cell carcinoma arising on human papillomavirus‐independent precursors mimicking high‐grade squamous intra‐epithelial lesion: a distinct and …

N Carreras‐Dieguez, A Saco, M Del Pino… - …, 2023 - Wiley Online Library
Aims Each category of vulvar squamous cell carcinoma (VSCC), human papillomavirus
(HPV)‐associated and HPV‐independent, arises on a specific intra‐epithelial precursor …

An update on vulvar intraepithelial neoplasia: terminology and a practical approach to diagnosis

MC Reyes, K Cooper - Journal of clinical pathology, 2014 - jcp.bmj.com
There are two distinct types of vulvar intraepithelial neoplasia (VIN), which differ in their
clinical presentation, aetiology, pathogenesis and histological/immunophenotypical …

Differentiated vulvar intraepithelial neoplasia-like and lichen sclerosus-like lesions in HPV-associated squamous cell carcinomas of the vulva

N Rakislova, L Alemany, O Clavero… - The American Journal …, 2018 - journals.lww.com
Most human papillomavirus (HPV)-associated vulvar squamous cell carcinomas (VSCCs)
originate from high-grade squamous intraepithelial lesions, also named usual type vulvar …

DEVIL, VAAD and vLSC constitute a spectrum of HPV‐independent, p53‐independent intra‐epithelial neoplasia of the vulva

SF Roy, J Wong, C Le Page, D Tran‐Thanh… - …, 2021 - Wiley Online Library
Aims We aimed to characterise a large cohort of non‐invasive, human papillomavirus (HPV)
and p53‐independent verruciform lesions, such as 'vulvar acanthosis with altered …

[HTML][HTML] Classification of vulvar squamous cell carcinoma and precursor lesions by p16 and p53 immunohistochemistry: considerations, caveats, and an algorithmic …

H Yang, N Almadani, EF Thompson, B Tessier-Cloutier… - Modern Pathology, 2023 - Elsevier
There is emerging evidence that vulvar squamous cell carcinoma (VSCC) can be
prognostically subclassified into 3 groups based on human papillomavirus (HPV) and p53 …

Expanding the morphologic, immunohistochemical, and HPV genotypic features of high-grade squamous intraepithelial lesions of the vulva with morphology …

LM Griesinger, H Walline, GY Wang… - International Journal …, 2021 - journals.lww.com
Squamous cell carcinoma of the vulva can arise through 2 pathways: human papillomavirus
(HPV)-dependent high-grade squamous intraepithelial lesions (previously termed usual …

Human papillomavirus and p53 status define three types of vulvar squamous cell carcinomas with distinct clinical, pathological, and prognostic features

N Carreras‐Dieguez, A Saco, M Del Pino… - …, 2023 - Wiley Online Library
Introduction Based on their etiological relationship with human papillomavirus (HPV), the
2020 WHO classification has divided vulvar squamous cell carcinomas (VSCC) into two …

[HTML][HTML] Precursor lesions of vulvar squamous cell carcinoma–histology and biomarkers: A systematic review

S Dasgupta, PC Ewing-Graham… - Critical Reviews in …, 2020 - Elsevier
The precursor lesion of vulvar squamous cell carcinoma (VSCC), namely vulvar
intraepithelial neoplasia (VIN), is classified as: human papillomavirus (HPV)-related high …