Commentary: IL-4 and IL-13 receptors and signaling
SM McCormick, NM Heller - Cytokine, 2015 - Elsevier
Abstract Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 …
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 …
Tuning the cytokine responses: an update on interleukin (IL)-4 and IL-13 receptor complexes
IS Junttila - Frontiers in immunology, 2018 - frontiersin.org
Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic
inflammation. They play important roles in regulating the responses of lymphocytes, myeloid …
inflammation. They play important roles in regulating the responses of lymphocytes, myeloid …
IL-4 and IL-13: their pathological roles in allergic diseases and their potential in developing new therapies
K Izuhara, K Arima, S Yasunaga - Current Drug Targets …, 2002 - ingentaconnect.com
The incidence of allergic diseases has dramatically increased in recent decades, and it is
socially and medically important to establish more useful strategies to overcome allergic …
socially and medically important to establish more useful strategies to overcome allergic …
IL-13 receptors and signaling pathways: an evolving web
GKK Hershey - Journal of Allergy and Clinical Immunology, 2003 - Elsevier
Continuing Medical Education examination IL-13 is an immunoregulatory cytokine secreted
predominantly by activated TH2 cells. Over the past several years, it has become evident …
predominantly by activated TH2 cells. Over the past several years, it has become evident …
An update on interleukin-4 and its receptor
P Chomarat, J Banchereau - European cytokine network, 1997 - jle.com
Interleukin-4 (IL-4) exhibits many biological and immunoregulatory functions on B
lymphocytes, monocytes, dendritic cells and fibroblasts. The IL-4 gene is located on …
lymphocytes, monocytes, dendritic cells and fibroblasts. The IL-4 gene is located on …
Immunoregulatory properties of IL-13: its potential role in atopic disease
JE de Vries, G Zurawski - International archives of allergy and …, 1995 - karger.com
IL-13 is a relatively novel cytokine produced by activated T cells. IL-13 inhibits the
production of proinflammatory cytokines and chemokines by activated monocytes, induces B …
production of proinflammatory cytokines and chemokines by activated monocytes, induces B …
[HTML][HTML] Recent advances in understanding the role of IL-4 signaling
Abstract Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic
actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells …
actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells …
IL-13 as a therapeutic target for respiratory disease
MT Kasaian, DK Miller - Biochemical pharmacology, 2008 - Elsevier
Interleukin-13 (IL-13) is a critical mediator of asthma pathology. On B cells, monocytes,
epithelial cells, and smooth muscle cells, IL-13 acts through the IL-13Rα1/IL-4Rα complex to …
epithelial cells, and smooth muscle cells, IL-13 acts through the IL-13Rα1/IL-4Rα complex to …
Interleukin-13 as an important cytokine: A review on its roles in some human diseases
N Seyfizadeh, N Seyfizadeh, T Gharibi… - Acta microbiologica et …, 2015 - akjournals.com
Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to
induce activation responses which contribute to the inflammatory diseases. Genetic …
induce activation responses which contribute to the inflammatory diseases. Genetic …
Interleukins-4,-5, and-13: emerging therapeutic targets in allergic disease
For the first time, allergic diseases have emerged as major public health concerns. Highly
effective therapies for allergic disease now exist, but are plagued by serious side effects and …
effective therapies for allergic disease now exist, but are plagued by serious side effects and …