[HTML][HTML] Challenges and opportunities for large-scale electrophysiology with Neuropixels probes

NA Steinmetz, C Koch, KD Harris… - Current opinion in …, 2018 - Elsevier
Electrophysiological methods are the gold standard in neuroscience because they reveal
the activity of individual neurons at high temporal resolution and in arbitrary brain locations …

Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

NA Steinmetz, C Aydin, A Lebedeva, M Okun… - Science, 2021 - science.org
INTRODUCTION Electrode arrays based on complementary metal-oxide semiconductor
silicon fabrication technology, such as Neuropixels probes, have enabled recordings of …

Active pixel sensor array for high spatio-temporal resolution electrophysiological recordings from single cell to large scale neuronal networks

L Berdondini, K Imfeld, A Maccione, M Tedesco… - Lab on a Chip, 2009 - pubs.rsc.org
This paper presents a chip-based electrophysiological platform enabling the study of micro-
and macro-circuitry in in-vitro neuronal preparations. The approach is based on a 64× 64 …

Revealing neuronal function through microelectrode array recordings

MEJ Obien, K Deligkaris, T Bullmann… - Frontiers in …, 2015 - frontiersin.org
Microelectrode arrays and microprobes have been widely utilized to measure neuronal
activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate …

Modified Neuropixels probes for recording human neurophysiology in the operating room

B Coughlin, W Muñoz, Y Kfir, MJ Young, D Meszéna… - Nature …, 2023 - nature.com
Neuropixels are silicon-based electrophysiology-recording probes with high channel count
and recording-site density. These probes offer a turnkey platform for measuring neural …

A nanoelectrode array for obtaining intracellular recordings from thousands of connected neurons

J Abbott, T Ye, K Krenek, RS Gertner, S Ban… - Nature biomedical …, 2020 - nature.com
Current electrophysiological or optical techniques cannot reliably perform simultaneous
intracellular recordings from more than a few tens of neurons. Here we report a …

Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

AC Paulk, Y Kfir, AR Khanna, ML Mustroph… - Nature …, 2022 - nature.com
Recent advances in multi-electrode array technology have made it possible to monitor large
neuronal ensembles at cellular resolution in animal models. In humans, however, current …

Acute head-fixed recordings in awake mice with multiple Neuropixels probes

S Durand, GR Heller, TK Ramirez, JA Luviano… - Nature …, 2023 - nature.com
Multi-electrode arrays such as Neuropixels probes enable electrophysiological recordings
from large populations of single neurons with high temporal resolution. By using such …

[HTML][HTML] High-density single-unit human cortical recordings using the Neuropixels probe

JE Chung, KK Sellers, MK Leonard, L Gwilliams, D Xu… - Neuron, 2022 - cell.com
The action potential is a fundamental unit of neural computation. Even though significant
advances have been made in recording large numbers of individual neurons in animal …

High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays

J Du, IH Riedel-Kruse, JC Nawroth… - Journal of …, 2009 - journals.physiology.org
Microelectrode array recordings of neuronal activity present significant opportunities for
studying the brain with single-cell and spike-time precision. However, challenges in device …