Chromatin remodelers regulate genes by organizing nucleosomes around promoters, but
their individual contributions are obfuscated by the complex in vivo milieu of factor …

How chromatin remodelers cooperate to organize nucleosomes around the start and end of
genes is not known. We determined the genome-wide binding of remodeler complexes …

The chromatin landscape and promoter architecture are dominated by the interplay of
nucleosome and transcription factor (TF) binding to crucial DNA sequence elements …

Nucleosome organization has a key role in transcriptional regulation, yet the precise
mechanisms establishing nucleosome locations and their effect on transcription are unclear …

Arrays of regularly spaced nucleosomes dominate chromatin and are often phased by
alignment to reference sites like active promoters. How the distances between nucleosomes …

The fundamental molecular determinants by which ATP-dependent chromatin remodelers
organize nucleosomes across eukaryotic genomes remain largely elusive. Here, chromatin …

Gene regulation in eukaryotes requires the controlled access of sequence-specific
transcription factors (TFs) to their sites in a chromatin landscape dominated by …

ATP-dependent nucleosome remodelers influence genetic processes by altering
nucleosome occupancy, positioning, and composition. In vitro, Saccharomyces cerevisiae …

Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes.
However, our understanding of how these processes (for example, DNA replication, RNA …

Genetic information in eukaryotes is managed by strategic hierarchical organization of
chromatin structure. Primary chromatin structure describes an unfolded nucleosomal array …