The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal
contents to the subepithelium. In addition, the epithelium dictates the initial responses of the …

The pulmonary epithelial and vascular endothelial cell layers provide two sequential
physical and immunological barriers that together form a semi‐permeable interface and …

Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Pulmonary endothelium forms a semiselective barrier that regulates fluid balance and
leukocyte trafficking. During the course of lung inflammation, neurohumoral mediators and …

Tight junctions create regulated barriers in the paracellular space between epithelial cells,
including those of the airway and alveolus. Junctions vary widely throughout the body in …

In the last 10 years, since the National Heart, Lung, and Blood Institute (NHLBI) convened a
workshop focused on mechanisms of alveolar microvascular injury (1), there has been an …

The lungs provide a large inner surface to guarantee respiration. In lung alveoli, a delicate
membrane formed by endo-and epithelial cells with their fused basal lamina ensures rapid …

The lung interfaces with the environment across a continuous epithelium composed of
various cell types along the proximal and distal airways. At the alveolar structure level, the …

Alterations of cell monolayer integrity and increased vascular permeability are key to many
pathologies, including atherosclerosis, stroke, lung injury, cancer, digestive disorders and …

Increased endothelial permeability and reduction of alveolar liquid clearance capacity are
two leading pathogenic mechanisms of pulmonary edema, which is a major complication of …