Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis
Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in breast cancer, and …
The RNA-binding protein HuR in human cancer: a friend or foe?
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …
elements present in mRNAs whose stability and translation are subject to regulation. The …
Targeting the RNA-binding protein HuR in cancer
The RNA-binding protein human antigen R (HuR) is a well-established regulator of gene
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
expression at the posttranscriptional level. Its dysregulation has been implicated in various …
Small molecules targeting the RNA-binding protein HuR inhibit tumor growth in xenografts
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in
several types of diseases, including cancer, making it a promising therapeutic target. We …
several types of diseases, including cancer, making it a promising therapeutic target. We …
[HTML][HTML] Current evidence and future perspectives on HuR and breast cancer development, prognosis, and treatment
I Kotta-Loizou, SN Vasilopoulos, RHA Coutts… - Neoplasia, 2016 - Elsevier
Hu-antigen R (HuR) is an RNA-binding posttranscriptional regulator that belongs to the
Hu/ELAV family. HuR expression levels are modulated by a variety of proteins, microRNAs …
Hu/ELAV family. HuR expression levels are modulated by a variety of proteins, microRNAs …
The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer
Background The discordance between steady-state levels of mRNAs and protein has been
attributed to posttranscriptional control mechanisms affecting mRNA stability and translation …
attributed to posttranscriptional control mechanisms affecting mRNA stability and translation …
Overexpression of the RNA binding protein HuR impairs tumor growth in triple negative breast cancer associated with deficient angiogenesis
Interactions between RNA binding proteins (RBPs) and genes are not well understood,
especially in regulation of angiogenesis. The RBP HuR binds to the AU-rich (ARE) regions …
especially in regulation of angiogenesis. The RBP HuR binds to the AU-rich (ARE) regions …
HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA
Z Zhang, A Huang, A Zhang, C Zhou - Biomedicine & Pharmacotherapy, 2017 - Elsevier
HuR, a ubiquitously expressed RNA-binding protein, stabilizes mRNA and regulates its
translation. HuR expression was increased at all stages of breast cancer and correlated with …
translation. HuR expression was increased at all stages of breast cancer and correlated with …
The RNA binding protein HuR: a promising drug target for anticancer therapy
M Wu, CWS Tong, W Yan, KKW To… - Current cancer drug …, 2019 - ingentaconnect.com
The stability of mRNA is one of the key factors governing the regulation of eukaryotic gene
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
expression and function. Human antigen R (HuR) is an RNA-binding protein that regulates …
Role of RNA binding protein HuR in ductal carcinoma in situ of the breast
M Heinonen, A Hemmes, K Salmenkivi… - The Journal of …, 2011 - Wiley Online Library
HuR is a ubiquitously expressed RNA‐binding protein that modulates gene expression at
the post‐transcriptional level. It is predominantly nuclear, but can shuttle between the …
the post‐transcriptional level. It is predominantly nuclear, but can shuttle between the …