Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

Z Chen, R Tian, Z She, J Cai, H Li - Free Radical Biology and Medicine, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common chronic liver
disease worldwide and is strongly associated with the presence of oxidative stress …

Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis

S Spahis, E Delvin, JM Borys, E Levy - Antioxidants & redox …, 2017 - liebertpub.com
Significance: Nonalcoholic fatty liver disease (NAFLD), characterized by liver triacylglycerol
build-up, has been growing in the global world in concert with the raised prevalence of …

Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: Implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021 - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …

Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities

R Gambino, G Musso, M Cassader - Antioxidants & redox signaling, 2011 - liebertpub.com
Nonalcoholic fatty liver disease (NAFLD) is currently the most common liver disease in the
world. It encompasses a histological spectrum, ranging from simple, nonprogressive …

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

AP Rolo, JS Teodoro, CM Palmeira - Free radical biology and medicine, 2012 - Elsevier
The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …

Endoplasmic reticulum stress and oxidative stress in the pathogenesis of non-alcoholic fatty liver disease

NU Ashraf, TA Sheikh - Free radical research, 2015 - Taylor & Francis
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome. The underlying causes of the disease progression in NAFLD are unclear. Recent …

Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship

A Karkucinska‐Wieckowska… - European journal of …, 2022 - Wiley Online Library
According to the 'multiple‐hit'hypothesis, several factors can act simultaneously in
nonalcoholic fatty liver disease (NAFLD) progression. Increased nitro‐oxidative (nitroso …

The role and mechanism of oxidative stress and nuclear receptors in the development of NAFLD

T Hong, Y Chen, X Li, Y Lu - Oxidative medicine and cellular …, 2021 - Wiley Online Library
The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

Role of oxidative stress in hepatic and extrahepatic dysfunctions during nonalcoholic fatty liver disease (NAFLD)

A Gonzalez, C Huerta-Salgado… - Oxidative Medicine …, 2020 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a pathology that contains a broad liver
dysfunctions spectrum. These alterations span from noninflammatory isolated steatosis until …