Epigenome‐wide association study of BMI in Black populations from InterGEN and GENOA

JY Taylor, Y Huang, W Zhao, ML Wright, Z Wang… - …, 2023 - Wiley Online Library
Objective Obesity is a significant public health concern across the globe. Research
investigating epigenetic mechanisms related to obesity and obesity‐associated conditions …

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

EW Demerath, W Guan, ML Grove… - Human molecular …, 2015 - academic.oup.com
Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …

Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians

W Li, M Xia, H Zeng, H Lin, AE Teschendorff, X Gao… - Clinical …, 2024 - Springer
Background Obesity is a global public health concern linked to chronic diseases such as
cardiovascular disease and type 2 diabetes (T2D). Emerging evidence suggests that …

Impact of BMI and waist circumference on epigenome-wide DNA methylation and identification of epigenetic biomarkers in blood: an EWAS in multi-ethnic Asian …

Y Chen, I Kassam, SH Lau, JS Kooner, R Wilson… - Clinical …, 2021 - Springer
Background The prevalence of obesity and its related chronic diseases have been
increasing especially in Asian countries. Obesity-related genetic variants have been …

DNA methylation and obesity traits: An epigenome-wide association study. The REGICOR study

S Sayols-Baixeras, I Subirana, A Fernández-Sanlés… - Epigenetics, 2017 - Taylor & Francis
Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …

DNA methylome profiling in identical twin pairs discordant for body mass index

W Li, D Zhang, W Wang, Y Wu… - International journal of …, 2019 - nature.com
Objective Body mass index (BMI) serves as an important measurement of obesity and
adiposity, which are highly correlated with cardiometabolic diseases. Although high …

Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI

WL Do, D Sun, K Meeks, PA Dugué, E Demerath… - The American Journal of …, 2023 - cell.com
This study sought to examine the association between DNA methylation and body mass
index (BMI) and the potential of BMI-associated cytosine-phosphate-guanine (CpG) sites to …

DNA methylation and adiposity phenotypes: an epigenome-wide association study among adults in the Strong Heart Study

KC Crocker, A Domingo-Relloso, K Haack… - International Journal of …, 2020 - nature.com
Background Elevated adiposity is often posited by medical and public health researchers to
be a risk factor associated with cardiovascular disease, diabetes, and other diseases. These …

An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression

X Wang, Y Pan, H Zhu, G Hao, Y Huang, V Barnes… - Clinical …, 2018 - Springer
Background We conducted an epigenome-wide association study (EWAS) on obesity in
healthy youth and young adults and further examined to what extent identified signals …

Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers

S Voisin, MS Almén, GY Zheleznyakova, L Lundberg… - Genome medicine, 2015 - Springer
Background The mechanisms by which genetic variants, such as single nucleotide
polymorphisms (SNPs), identified in genome-wide association studies act to influence body …