The ECM: to scaffold, or not to scaffold, that is the question

JC Valdoz, BC Johnson, DJ Jacobs, NA Franks… - International Journal of …, 2021 - mdpi.com
The extracellular matrix (ECM) has pleiotropic effects, ranging from cell adhesion to cell
survival. In tissue engineering, the use of ECM and ECM-like scaffolds has separated the …

Extracellular matrix as an inductive scaffold for functional tissue reconstruction

BN Brown, SF Badylak - Translational Research, 2014 - Elsevier
The extracellular matrix (ECM) is a meshwork of both structural and functional proteins
assembled in unique tissue-specific architectures. The ECM both provides the mechanical …

[HTML][HTML] Engineering ECM signals into biomaterials

RJ Wade, JA Burdick - Materials Today, 2012 - Elsevier
Historically, tissue engineering focused primarily on the delivery of soluble factors within
relatively static scaffolds; yet, increasing evidence indicates that the native, dynamic three …

Decellularized Extracellular Matrix as an In Vitro Model to Study the Comprehensive Roles of the ECM in Stem Cell Differentiation

T Hoshiba, G Chen, C Endo, H Maruyama… - Stem cells …, 2016 - Wiley Online Library
Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation
must be regulated for applications in regenerative medicine. Stem cells are surrounded by …

Extracellular matrix-derived biomaterials in engineering cell function

H Xing, H Lee, L Luo, TR Kyriakides - Biotechnology advances, 2020 - Elsevier
Extracellular matrix (ECM) derived components are emerging sources for the engineering of
biomaterials that are capable of inducing desirable cell-specific responses. This review …

Extracellular matrix-based materials for regenerative medicine

GS Hussey, JL Dziki, SF Badylak - Nature Reviews Materials, 2018 - nature.com
In tissue engineering and regenerative medicine, a biomaterial provides mechanical support
and biochemical signals to encourage cell attachment and modulate cell behaviour …

Decellularized matrices as cell-instructive scaffolds to guide tissue-specific regeneration

KP Robb, A Shridhar, LE Flynn - ACS Biomaterials science & …, 2017 - ACS Publications
Decellularized scaffolds are promising clinically translational biomaterials that can be
applied to direct cell responses and promote tissue regeneration. Bioscaffolds derived from …

Evolution of biomimetic ECM scaffolds from decellularized tissue matrix for tissue engineering: A comprehensive review

Y Zhang, C Zhang, Y Li, L Zhou, N Dan, J Min… - International Journal of …, 2023 - Elsevier
Tissue engineering is essentially a technique for imitating nature. Natural tissues are made
up of three parts: extracellular matrix (ECM), signaling systems, and cells. Therefore …

[HTML][HTML] Biofabrication methods for reconstructing extracellular matrix mimetics

A Aazmi, D Zhang, C Mazzaglia, M Yu, Z Wang… - Bioactive Materials, 2024 - Elsevier
In the human body, almost all cells interact with extracellular matrices (ECMs), which have
tissue and organ-specific compositions and architectures. These ECMs not only function as …

Controlling stem cell behavior with decellularized extracellular matrix scaffolds

G Agmon, KL Christman - Current Opinion in Solid State and Materials …, 2016 - Elsevier
Decellularized tissues have become a common regenerative medicine platform with multiple
materials being researched in academic laboratories, tested in animal studies, and used …