Context.—Lung cancer is the number one cause of cancer deaths in the United States and
globally. The advent of targeted therapies has offered a new treatment paradigm for lung …

With the advent of targeted therapies directed towards folate receptor alpha, with several
such agents in late stage clinical development, the sensitive and robust detection of folate …

Context.—Folate receptor α (FRA) is a glycosylphosphatidylinositol-anchored high-affinity
folate receptor that localizes to the apical surface of epithelia when it is expressed in normal …

Background To evaluate the prognostic value of folate receptor α (FOLR1) and/or reduced
folate carrier (RFC1) expression, which are well-characterized folate transporters, in …

In the past year, gp38, a glycosyl-phosphatidylinositol linked membrane protein that is
overexpressed in some malignant tissues, has been shown to be the folate receptor. Using …

Introduction: Folate receptor alpha (FRα) and reduced folate carrier-1 (RFC1) regulate
uptake of folate molecules inside the cell. FRα is a potential biomarker of tumors response to …

Human folate receptor (hFR, folate‐binding protein) is a single‐chain glycoprotein with high
specific affinity for folk acid and methotrexate. We have created 4 monoclonal antibodies …

Background Nanotechnology‐based drug delivery approaches may help increase
therapeutic efficacy and decrease side effects of chemotherapeutics. We investigated …

Objective: To determine whether the folate receptor gene is overexpressed in malignant
pleural mesothelioma. Methods: Differential display analysis was performed with fresh …

Background In cancer therapy, molecularly targeted agents have the potential to maximize
antitumor efficacy while minimizing treatment-related toxicity. However, these agents may …