Neuroimmune communication of the enteric nervous system (ENS) in gut-associated
lymphoid tissues helps to maintain the delicate balance between gut inflammation and …

Background The neurotransmitter substance P (SP) released by, and the transient receptor
potential vanilloid (TRPV1), expressed by afferent nerves, have been implicated in mucosal …

It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the
normal immune repertoire, preventing the development of pathogenic responses to both self …

The chemokine receptor CCR9 and its only known ligand CCL25 play an important role in
gut inflammation and autoimmune colitis. The function of CCR9‐CCL25 in the migration of …

Background & Aims: It has been unclear which chemokine network is involved in migration
of T-cell subsets to chronically inflamed lesions of the intestine. SAMP1/YP mice develop a …

Significant interactions may occur between the “immune and nervous systems in the gut”;
which include glia, intrinsic and extrinsic neurons, and various immune cells located in close …

Thymic induction of CD4+ Foxp3+ regulatory T (Treg) cells relies on CD28 costimulation and
high-affinity T-cell receptor (TCR) signals, whereas Foxp3 (forkhead box P3) induction on …

Dysregulation of mucosal immune system has been proposed to be critical in the
pathogenesis of inflammatory bowel diseases (IBDs). Regulatory T cells (Tregs) play an …

Abstract Background and Aims Tyrosine kinase 2 [TYK2] is required for the signalling of key
cytokines in the pathogenesis of inflammatory bowel disease [IBD]. We assessed the …

CD4+ Tregs need to migrate from the mucosal periphery into the draining lymph node via
CCR7 to exert their suppressive effects. In this study, we investigated whether CCR7 …