Anti-cancer effect and underlying mechanism (s) of kaempferol, a phytoestrogen, on the regulation of apoptosis in diverse cancer cell models
SH Kim, KC Choi - Toxicological research, 2013 - Springer
Phytoestrogens exist in edible compounds commonly found in fruits or plants. For long
times, phytoestrogens have been used for therapeutic treatments against human diseases …
times, phytoestrogens have been used for therapeutic treatments against human diseases …
Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway
H Luo, GO Rankin, Z Li, L DePriest, YC Chen - Food Chemistry, 2011 - Elsevier
Ovarian cancer is a significant malignancy for women in the Western world, and its death
rate has remained unchanged over the past 50 years, leaving room for proper …
rate has remained unchanged over the past 50 years, leaving room for proper …
[HTML][HTML] Kaempferol suppresses proliferation and induces cell cycle arrest, apoptosis, and DNA damage in breast cancer cells
L Zhu, L Xue - Oncology research, 2019 - ncbi.nlm.nih.gov
Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor
effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to …
effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to …
[HTML][HTML] Kaempferol induces G2/M cell cycle arrest via checkpoint kinase 2 and promotes apoptosis via death receptors in human ovarian carcinoma A2780/CP70 …
Y Gao, J Yin, GO Rankin, YC Chen - Molecules, 2018 - mdpi.com
Kaempferol is a widely distributed dietary flavonoid. Epidemiological studies have
demonstrated kaempferol consumption lowers the risk of ovarian cancer. Our previous …
demonstrated kaempferol consumption lowers the risk of ovarian cancer. Our previous …
Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes
HWC Leung, CJ Lin, MJ Hour, WH Yang… - Food and Chemical …, 2007 - Elsevier
Kaempferol (3, 4′, 5, 7-tetrahydroxyflavone) is one of the most commonly found dietary
flavonols. The biological and pharmacological effects of kaempferol may depend upon its …
flavonols. The biological and pharmacological effects of kaempferol may depend upon its …
Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K/AKT and telomerase pathways
E Kashafi, M Moradzadeh, A Mohamadkhani… - Biomedicine & …, 2017 - Elsevier
Cervical cancer is one of the most frequent cancers in women worldwide. Defects in the
apoptotic pathways are responsible for both the disease pathogenesis and its therapy …
apoptotic pathways are responsible for both the disease pathogenesis and its therapy …
[HTML][HTML] Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells
EJ Choi, WS Ahn - Nutrition research and practice, 2008 - ncbi.nlm.nih.gov
The aim of present study was to investigate the effects of kaempferol on cellular proliferation
and cell cycle arrest and explore the mechanism for these effects in human breast …
and cell cycle arrest and explore the mechanism for these effects in human breast …
[HTML][HTML] Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
HS Lee, HJ Cho, R Yu, KW Lee, HS Chun… - International journal of …, 2014 - mdpi.com
We previously noted that kaempferol, a flavonol present in vegetables and fruits, reduced
cell cycle progression of HT-29 cells. To examine whether kaempferol induces apoptosis of …
cell cycle progression of HT-29 cells. To examine whether kaempferol induces apoptosis of …
Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria‐dependent pathway in human osteosarcoma U‐2 OS cells
Kaempferol is a natural flavonoid. Previous studies have reported that kaempferol has anti‐
proliferation activities and induces apoptosis in many cancer cell lines. However, there are …
proliferation activities and induces apoptosis in many cancer cell lines. However, there are …
Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated …
W Li, B Du, T Wang, S Wang, J Zhang - Chemico-Biological Interactions, 2009 - Elsevier
Dietary flavonols have been found to possess preventive and therapeutic potential against
several kinds of cancers. This study is conducted to investigate the anti-proliferation effects …
several kinds of cancers. This study is conducted to investigate the anti-proliferation effects …