[HTML][HTML] Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know

WM Zelek, RA Harrison - Immunobiology, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …

COVID-19: complement, coagulation, and collateral damage

MW Lo, C Kemper, TM Woodruff - The Journal of Immunology, 2020 - journals.aai.org
Abstract Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory
infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although …

An update: the emerging evidence of complement involvement in COVID-19

Q Li, Z Chen - Medical Microbiology and Immunology, 2021 - Springer
The current outbreak of coronavirus disease 2019 (COVID-19) has affected people around
the world. Typically, COVID-19 originates in the lung, but lately it can extend to other organs …

Pharmacotherapy in COVID 19: potential impact of targeting the complement system

CM Barkoff, SA Mousa - Biomedicines, 2020 - mdpi.com
Coronavirus disease 2019 (COVID-19), a respiratory illness caused by infection with severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has claimed over one million lives …

[HTML][HTML] The complement system in COVID-19: friend and foe?

A Java, AJ Apicelli, MK Liszewski, A Coler-Reilly… - JCI insight, 2020 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19), the disease caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a …

The state of complement in COVID-19

B Afzali, M Noris, BN Lambrecht… - Nature Reviews …, 2022 - nature.com
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

Complement factors in COVID-19 therapeutics and vaccines

L Kurtovic, JG Beeson - Trends in immunology, 2021 - cell.com
Complement is integral to a healthy functioning immune system and orchestrates various
innate and adaptive responses against viruses and other pathogens. Despite its importance …

Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection

L Ma, SK Sahu, M Cano, V Kuppuswamy, J Bajwa… - Science …, 2021 - science.org
Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2
infection. However, it remains to be determined whether increased complement activation is …

Complement as a target in COVID-19?

AM Risitano, DC Mastellos, M Huber-Lang… - Nature Reviews …, 2020 - nature.com
Complement as a target in COVID-19? | Nature Reviews Immunology Skip to main content
Thank you for visiting nature.com. You are using a browser version with limited support for CSS …

Tackling COVID‐19 infection through complement‐targeted immunotherapy

S Jodele, J Köhl - British Journal of Pharmacology, 2021 - Wiley Online Library
The complement system is an ancient part of innate immunity sensing highly pathogenic
coronaviruses by mannan‐binding lectin (MBL) resulting in lectin pathway activation and …