Effector CD8+ T cells are typically thought to be a homogenous group of cytotoxic cells that
produce interferon-(IFN) γ. However, recent findings have challenged this notion because …

Simple Summary While most cancer immunotherapies have focused on CD8+ T cells as the
main drivers of antitumor immunity, increasing evidence indicates that CD4+ T cells also …

Simple Summary Diverse evidence revealed that CD4+ T cells play an important role in
antitumor immunity by promoting or suppressing cytotoxic T cell responses. This review …

Cancer immunotherapy has revolutionised cancer treatment, with immune checkpoint
blockade (ICB) therapy and adoptive cell therapy (ACT) increasingly becoming standard of …

Our understanding of the importance of CD4+ T cells in orchestrating immune responses
has grown dramatically over the past decade. This lymphocyte family consists of diverse …

Whereas preclinical investigations and clinical studies have established that CD8+ T cells
can profoundly affect cancer progression, the underlying mechanisms are still elusive …

Recent advances in cancer immunotherapy—ranging from immune-checkpoint blockade
therapy to adoptive cellular therapy and vaccines—have revolutionized cancer treatment …

Cytotoxic T cells are important effectors of anti-tumor immunity. While tumor killing is
ascribed to CD8+ T cell function, pre-clinical and clinical studies have identified intra …

Over the past decades, tumor-resident immune cells have been extensively studied to
dissect their biological functions and clinical roles. Tumor-infiltrating CD8+ T cells, because …

Simple Summary This study seeks to evaluate innate T cells for antitumor therapies that can
target both tumor cells and immunosuppressive tumor-associated macrophages (TAMs) …