The calcineurin inhibitors (CNIs) tacrolimus and cyclosporine are widely used
immunosuppressive drugs characterized by high pharmacokinetic and pharmacodynamic …

Calcineurin inhibitors, tacrolimus (FK506) and cyclosporine (ciclosporin A), are the primary
immunosuppressive agents used on recipients of organ transplantations. The hepatic …

Since their introduction circa 35 years ago, calcineurin-inhibitors (CNI) have become the
cornerstone of immunosuppressive therapy in solid organ transplantation. However, CNI's …

Cyclosporine A and tacrolimus (Tac) are inmunosuppresive drugs with a narrow therapeutic
range. Underdosing is associated with organ rejection, whereas overdosing could result in …

Calcineurin inhibitors (CNIs), such as cyclosporine A and tacrolimus, are widely used
immunosuppressive agents for the prevention of post-transplantation rejection and have …

Chronic calcineurin inhibitor (CNI)-induced nephrotoxicity is associated with prolonged use
of cyclosporine and tacrolimus and has been observed after all types of transplantation, as …

The immunosuppressive drugs cyclosporin (CsA) and tacrolimus (Tac) are widely used to
prevent acute rejection following solid-organ transplantation. However, the clinical use of …

Background: Tacrolimus (Tac, or FK506), a calcineurin inhibitor (CNI), is the first-line
immunosuppressant which consists of the footstone as immunosuppressive regimens in …

Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation.
Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities …

The calcineurin inhibitors ciclosporin (cyclosporine) and tacrolimus are immunosuppressant
drugs used for the prevention of organ rejection following transplantation. Both agents are …