The rate of in vivo degradation was determined for a naturally occurring biomaterial derived
from the extracellular matrix of the small intestinal submucosa (SIS). The SIS was labeled by …

Small-intestinal submucosa (SIS) is a unique biomaterial that has been shown to induce
tissue-specific regeneration in numerous organ systems. In the urinary tract, animal studies …

Neuropathic bladders are the result from damages to the central or peripheral nervous
system, and ultimately may require surgical reconstruction to increase bladder volumes and …

The extracellular matrix (ECM) of porcine small intestinal submucosa (SIS) has been shown
to serve as a resorbable scaffold for tissue repair and remodeling in several body locations …

Tissue engineering is a promising field of research that has the potential to revolutionize
urinary bladder reconstruction. Currently, two techniques for the induction of bladder …

The need to find an alternative to the use of bowel for urinary reconstruction has renewed
research interests involving bladder regeneration. Historically, alloplastic and …

OBJECTIVES: This study determined the feasibility of promoting urinary bladder
regeneration with porcine-derived small intestinal submucosa (SIS). METHODS: Twenty-two …

A rabbit model was used for the evaluation of a collagen-based biomatrix of small intestinal
submucosa (SIS, COOK®) in comparison to a biochemically reconstructed biomatrix for …

In spite of long term clinical use of decellularized bladder submucosa matrix (BSM), little is
known about the active factors within this material. In this paper, we analyzed the biological …

PURPOSE:: Using the unseeded technique of tissue engineering, small intestinal
submucosa (SIS) has been shown to promote bladder regeneration. Initial studies using …