Synthesis and anticancer activity of novel derivatives of α, β‐unsaturated ketones based on oleanolic acid: in vitro and in silico studies against prostate cancer cells
Herein, new derivatives of α, β-unsaturated ketones based on oleanolic acid (4 ai) were
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
designed, synthesized, characterized, and tested against human prostate cancer (PC3) …
Novel β‑hydroxy ketones: Synthesis, spectroscopic characterization, molecular docking, and anticancer activity studies
In this study, a series of novel β‑hydroxy ketone derivatives 3a-o were designed,
synthesized, and evaluated for their anticancer activity. The structure of these compounds …
synthesized, and evaluated for their anticancer activity. The structure of these compounds …
Synthesis, structure characterization, DFT calculations, and computational anticancer activity investigations of 1-phenyl ethanol derivatives
Phenyl ethanol derivatives are well-known classes of drug molecules that play an important
role as effective substitute analogs to anticancer and antiviral agents. In this work …
role as effective substitute analogs to anticancer and antiviral agents. In this work …
Synthesis and antitumor activity of α, β-unsaturated carbonyl moiety-containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway
SS Wang, QL Zhang, P Chu, LQ Kong, GZ Li, YQ Li… - Bioorganic …, 2020 - Elsevier
Oleanolic acid (OA) and its semi-synthetic derivatives have been reported to have a wide
range of biological activities. The introduction of electrophilic Michael acceptor group can …
range of biological activities. The introduction of electrophilic Michael acceptor group can …
Antiproliferative Activities and SwissADME Predictions of Physicochemical Properties of Carbonyl Group‐Modified Rotenone Analogues
RD Hernandez, FAF Genio, JR Casanova… - …, 2024 - Wiley Online Library
Rotenone is a naturally occurring compound shown to exhibit antiproliferative activity
against various cancer cell lines, indicating its potential as a lead anticancer agent …
against various cancer cell lines, indicating its potential as a lead anticancer agent …
Synthesis, Computational, and Anticancer In Vitro Investigations of Aminobenzylnaphthols Derived from 2-Naphtol, Benzaldehydes, and α-Aminoacids via the Betti …
M Kciuk, M Malinowska, A Gielecińska, R Sundaraj… - Molecules, 2023 - mdpi.com
Multicomponent reactions have emerged as an important approach for the synthesis of
diverse and complicated chemical compounds. They have various advantages over two …
diverse and complicated chemical compounds. They have various advantages over two …
Synthesis and cytotoxicity evaluation of oleanolic acid derivatives
J Hao, J Liu, X Wen, H Sun - Bioorganic & medicinal chemistry letters, 2013 - Elsevier
Twelve derivatives of oleanolic acid (1) have been synthesized and evaluated for their
inhibitory activities against the growth of prostate PC3, breast MCF-7, lung A549, and gastric …
inhibitory activities against the growth of prostate PC3, breast MCF-7, lung A549, and gastric …
[PDF][PDF] In silico studies on the molecular geometry, FMO, mulliken charges, MESP, ADME and molecular docking prediction of pyrogallol carboxaldehydes as potential …
AR Kumara, CS Selvib, S Selvarajc, GPS Mold… - Phys. Chem …, 2024 - physchemres.org
In this study, quantum-chemical computational calculations were performed to evaluate the
electronic structures of pyrogallol carboxaldehydes, specifically the pyrogallol-4 …
electronic structures of pyrogallol carboxaldehydes, specifically the pyrogallol-4 …
Investigation on 5-Isopropyl-2-methylphenol via quantum chemicals, pharmacokinetics, molecular docking and cytotoxicity evaluation against breast cancer
K Chandran, A Zochedh, AB Sultan… - Journal of …, 2024 - ui.adsabs.harvard.edu
Abstract The 5-isopropyl-2-methylphenol (5IP2MP) molecule, a monoterpenoid phenol
mostly existing in the essential oil of Origanum vulgare L., was used as a potent breast …
mostly existing in the essential oil of Origanum vulgare L., was used as a potent breast …
In silico design of novel bioactive molecules to treat breast cancer with chlorogenic acid derivatives: a computational and SAR approach
Introduction: Cancer is a vast group of diseases comprising abnormal cells that multiply and
grow uncontrollably, and it is one of the top causes of death globally. Several types of …
grow uncontrollably, and it is one of the top causes of death globally. Several types of …