Extracellular matrix (ECM) is a complex and dynamic network of proteoglycans, proteins,
and other macromolecules that surrounds cells in tissues. The ECM provides structural …

Central nervous system (CNS) injury results in chronic scar formation that interferes with
function and inhibits repair. Extracellular matrix (ECM) is prominent in the scar and potently …

After traumatic injuries to the nervous system, regrowing axons encounter a complex
microenvironment where mechanisms that promote regeneration compete with inhibitory …

Contrary to established dogma, the central nervous system (CNS) has a capacity for
regeneration and is moderately plastic. Traditionally, such changes have been recognized …

The extracellular matrix (ECM) is a protein-and-carbohydrate meshwork that supports a
variety of biological structures and processes, from tissue development and elasticity to the …

The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult
brain by providing structural support and mediating cell‐cell interactions. In this review, we …

Significance: Traumatic spinal cord injury (SCI) causes significant disruption to neuronal,
glial, vascular, and extracellular elements. The spinal cord extracellular matrix (ECM) …

Central nervous system (CNS) injuries are often devastating as functional recovery via
axonal regrowth over the lesion site is very minimal. Failure of regeneration by injured CNS …

Brain and spinal cord injury can result in permanent cognitive, motor, sensory and
autonomic deficits. The central nervous system (CNS) has a poor intrinsic capacity for …

Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …