Genetic profile of advanced thyroid cancers in relation to distant metastasis

E Song, DE Song, J Ahn, TY Kim… - Endocrine-related …, 2020 - erc.bioscientifica.com
Major clinical challenges exist with differentiated thyroid cancers with distant metastases or
rare but aggressive types, such as poorly differentiated thyroid carcinomas and anaplastic …

Genomic profiling of primary and metastatic thyroid cancers

V Máximo, M Melo, Y Zhu, A Gazzo… - Endocrine-Related …, 2024 - erc.bioscientifica.com
The genetic repertoire of primary thyroid cancers (TCs) is well documented, but there is a
considerable lack of molecular profiling in metastatic TCs. Here, we retrieved and analyzed …

TERT, BRAF, and NRAS in Primary Thyroid Cancer and Metastatic Disease

M Melo, A Gaspar da Rocha, R Batista… - The Journal of …, 2017 - academic.oup.com
Context Little is known about the frequency of key mutations in thyroid cancer metastases
and its relationship with the primary tumor genotype. Objectives To evaluate the frequency of …

Highly concordant key genetic alterations in primary tumors and matched distant metastases in differentiated thyroid cancer

SY Sohn, WY Park, HT Shin, JS Bae, CS Ki, YL Oh… - Thyroid, 2016 - liebertpub.com
Background: Distant metastases uncommonly occur in differentiated thyroid carcinoma
(DTC), but they are a frequent cause of thyroid cancer–related death. Genomic alterations in …

Whole-exome sequencing of matched primary and metastatic papillary thyroid cancer

T Masoodi, AK Siraj, S Siraj, S Azam, Z Qadri… - Thyroid, 2020 - liebertpub.com
Background: Distant metastasis is a rare occurrence in thyroid cancer, and it can be
associated with poor prognosis. The genomic repertoires of various solid malignancies have …

TERT promoter mutations identify a high-risk group in metastasis-free advanced thyroid carcinoma

C Bournaud, F Descotes, M Decaussin-Petrucci… - European Journal of …, 2019 - Elsevier
Background TERT promoter mutations are associated with adverse clinicopathological
characteristics in thyroid carcinomas and considered as a major indicator of poor outcomes …

Genomic landscape of metastatic papillary thyroid carcinoma and novel biomarkers for predicting distant metastasis

X Lan, H Bao, X Ge, J Cao, X Fan, Q Zhang… - Cancer …, 2020 - Wiley Online Library
Papillary thyroid carcinoma (PTC) is the most common malignancy of the thyroid gland, with
a relatively high cure rate. Distant metastasis (DM) of PTC is uncommon, but when it occurs …

Foundation one genomic interrogation of thyroid cancers in patients with metastatic disease requiring systemic therapy

NM Iñiguez-Ariza, S Jasim, MM Ryder… - The Journal of …, 2020 - academic.oup.com
Context Clinical applications of genomic assessment of thyroid cancers are rapidly evolving.
Objectives, Design, and Setting We studied tumor samples from patients with imminently …

Molecular alterations in thyroid carcinoma

MRH Al Rasheed, B Xu - Surgical pathology clinics, 2019 - surgpath.theclinics.com
Thyroid carcinoma is the most common cancer in the endocrine system. Recent advances,
using next-generation sequencing, have shed light on the molecular pathogenesis of thyroid …

Genomic profiling of aggressive thyroid cancer in association with its clinicopathological characteristics

JH Kim, JY Jeong, AN Seo, NJY Park, M Kim, JY Park - in vivo, 2022 - iv.iiarjournals.org
Background/Aim: Poorly differentiated thyroid carcinoma (PDTC), anaplastic thyroid
carcinoma (ATC), and advanced DTC have poor outcomes. Materials and Methods: We …