Publisher Summary This chapter focuses on the progress in the development of neurokinin
(NK) antagonists. The neurokinins substance P (SP), neurokinin A (NKA), and neurokinin B …

The study of tachykinin NK1 (substance P) receptor antagonists has emerged as a field of
great promise due to accumulating evidence that NK1 antagonists offer possible new …

The structurally related neuropeptides, substance P (SP), neurokinin A (NKA), and
neurokinin B (NKB), which belong to a family of molecules termed tachykinins and are …

The isolation of substance P (SP) in 1931, and the later discovery of its preferred neurokinin
(NK) 1 receptor, led to an intense research effort aimed at elucidating the biological role of …

A series of 21 peptides were synthesized and tested in a variety of isolated organs in order
to determine their potential as neurokinin-2 (NK-2) antagonists. The peptides have been …

The literature on tachykinin antagonists published during the second semester of 1994 is
reviewed with emphasis on the potential clinical indications for antagonists of the three …

Until late 1994, research on the neurokinin-3 (NK3) receptor, compared with that on
neurokinin-1 (NK1) and neurokinin-2 (NK2) receptors, received little attention, due, to a …

Publisher Summary The neurokinins, a class of peptide neurotransmitters, characterized by
the common C-terminal sequence Phe-X-Gly-Leu Met-NH 2, are widely distributed in the …

Neurokinins (NKs), also known as tachykinins (TKs), are members of a family of small
peptides sharing the common C-terminal amino acid sequence Phe-X-Gly-Leu-Met-NH2 (1 …

We compared the neurokinin 1 receptor (NK1R) antagonists aprepitant, CP-99994 [(2 S, 3
S)-3-(2-methoxybenzylamino)-2-phenylpiperidine], and ZD6021 [3-cyano-N-((2 S)-2-(3, 4 …