Long non-coding RNAs and microRNAs as crucial regulators in cardio-oncology

SB Nukala, J Jousma, Y Cho, WH Lee, SG Ong - Cell & Bioscience, 2022 - Springer
Cancer is one of the leading causes of morbidity and mortality worldwide. Significant
improvements in the modern era of anticancer therapeutic strategies have increased the …

Non-coding RNAs in cancer therapy-induced cardiotoxicity: Mechanisms, biomarkers, and treatments

W Sun, J Xu, L Wang, Y Jiang, J Cui, X Su… - Frontiers in …, 2022 - frontiersin.org
As a result of ongoing breakthroughs in cancer therapy, cancer patients' survival rates have
grown considerably. However, cardiotoxicity has emerged as the most dangerous toxic side …

Noncoding RNAs: potential regulators in cardioncology

S Chatterjee, SK Gupta, C Bär… - American Journal of …, 2019 - journals.physiology.org
Cancer is the leading cause of morbidity and mortality in the United States and globally.
Owing to improved early diagnosis and advances in oncological therapeutic options, the …

Noncoding RNAs in doxorubicin-induced cardiotoxicity and their potential as biomarkers and therapeutic targets

H Fa, W Chang, X Zhang, D Xiao, J Wang - Acta Pharmacologica Sinica, 2021 - nature.com
Anthracyclines, such as doxorubicin (DOX), are well known for their high efficacy in treating
multiple cancers, but their clinical usage is limited due to their potential to induce fatal …

MicroRNAs in cancer treatment-induced cardiotoxicity

L Pellegrini, S Sileno, M D'Agostino, E Foglio… - Cancers, 2020 - mdpi.com
Cancer treatment has made significant progress in the cure of different types of tumors.
Nevertheless, its clinical use is limited by unwanted cardiotoxicity. Aside from the …

Circular RNAs at the intersection of cancer and heart disease: potential therapeutic targets in cardio-oncology

D Neufeldt, S Cushman, C Bär… - Cardiovascular …, 2023 - academic.oup.com
Considerable progress has been made in managing cancer; however, with these
advancements comes the discovery of previously unknown adverse events. In particular, the …

Non‐coding RNAs: key players in cardiac disease

FP Kreutzer, J Fiedler, T Thum - The Journal of physiology, 2020 - Wiley Online Library
Molecular mechanisms underlying heart failure (HF) are only partly understood. Non‐coding
RNAs (ncRNAs) have been reported to control function and signalling routes in the …

[HTML][HTML] A novel onco-cardiological mouse model of lung cancer-induced cardiac dysfunction and its application in identifying potential roles of tRNA-derived small …

Q Wu, S Zou, W Liu, M Liang, Y Chen, J Chang… - Biomedicine & …, 2023 - Elsevier
An increasing body of research suggests cancer-induced cardiovascular diseases, leading
to the appearance of an interdisciplinary study known as onco-cardiology. Lung cancer has …

Long noncoding RNA LINC00339 aggravates doxorubicin-induced cardiomyocyte apoptosis by targeting MiR-484

J Li, L Li, X Li, S Wu - Biochemical and biophysical research …, 2018 - Elsevier
Abnormally expressed long noncoding RNAs (lncRNAs) has been recognized as one of the
key source in cardiac diseases. However, the role of lncRNA in doxorubicin (DOX)-induced …

Breast cancer treatment and adverse cardiac events: what are the molecular mechanisms?

L Roca-Alonso, L Pellegrino, L Castellano, J Stebbing - Cardiology, 2012 - karger.com
Cardiotoxicity associated with breast cancer treatment is an important concern in the
oncology clinic. Different types of anti-cancer therapies have recorded high rates of cardiac …