Modulating glycolysis to improve cancer therapy
Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …
dominant'metabolic profile to promote their survival and meet their requirements for energy …
Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy
CE Zois, AL Harris - Journal of molecular medicine, 2016 - Springer
Metabolic reprogramming is a hallmark of cancer cells and contributes to their adaption
within the tumour microenvironment and resistance to anticancer therapies. Recently …
within the tumour microenvironment and resistance to anticancer therapies. Recently …
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
N Hay - Nature Reviews Cancer, 2016 - nature.com
In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …
metabolism. This Review summarizes past and recent advances in our understanding of the …
Revisited metabolic control and reprogramming cancers by means of the warburg effect in tumor cells
Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …
Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression
Z Li, H Zhang - Cellular and molecular life sciences, 2016 - Springer
Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …
Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
L Sun, C Suo, S Li, H Zhang, P Gao - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …
Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy
AF Abdel-Wahab, W Mahmoud, RM Al-Harizy - Pharmacological research, 2019 - Elsevier
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …
Linking tumor glycolysis and immune evasion in cancer: emerging concepts and therapeutic opportunities
S Ganapathy-Kanniappan - Biochimica et Biophysica Acta (BBA)-Reviews …, 2017 - Elsevier
Metabolic reprogramming and immune evasion are two hallmarks of cancer. Metabolic
reprogramming is exemplified by cancer's propensity to utilize glucose at an exponential …
reprogramming is exemplified by cancer's propensity to utilize glucose at an exponential …
Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect
X Chen, L Li, Y Guan, J Yang, Y Cheng - Acta Pharmacologica Sinica, 2016 - nature.com
Tumor cells rely mainly on glycolysis for energy production even in the presence of sufficient
oxygen, a phenomenon termed the Warburg effect, which is the most outstanding …
oxygen, a phenomenon termed the Warburg effect, which is the most outstanding …
Cancer cell metabolism: implications for therapeutic targets
M Jang, SS Kim, J Lee - Experimental & molecular medicine, 2013 - nature.com
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a
phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in …
phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in …