Modulating glycolysis to improve cancer therapy

C Chelakkot, VS Chelakkot, Y Shin, K Song - International Journal of …, 2023 - mdpi.com
Cancer cells undergo metabolic reprogramming and switch to a 'glycolysis-
dominant'metabolic profile to promote their survival and meet their requirements for energy …

Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy

CE Zois, AL Harris - Journal of molecular medicine, 2016 - Springer
Metabolic reprogramming is a hallmark of cancer cells and contributes to their adaption
within the tumour microenvironment and resistance to anticancer therapies. Recently …

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

N Hay - Nature Reviews Cancer, 2016 - nature.com
In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …

Revisited metabolic control and reprogramming cancers by means of the warburg effect in tumor cells

A Fukushi, HD Kim, YC Chang, CH Kim - International journal of …, 2022 - mdpi.com
Aerobic glycolysis is an emerging hallmark of many human cancers, as cancer cells are
defined as a “metabolically abnormal system”. Carbohydrates are metabolically …

Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

Z Li, H Zhang - Cellular and molecular life sciences, 2016 - Springer
Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

L Sun, C Suo, S Li, H Zhang, P Gao - … et Biophysica Acta (BBA)-Reviews on …, 2018 - Elsevier
While metabolic reprogramming of cancer cells has long been considered from the
standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis …

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

AF Abdel-Wahab, W Mahmoud, RM Al-Harizy - Pharmacological research, 2019 - Elsevier
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Linking tumor glycolysis and immune evasion in cancer: emerging concepts and therapeutic opportunities

S Ganapathy-Kanniappan - Biochimica et Biophysica Acta (BBA)-Reviews …, 2017 - Elsevier
Metabolic reprogramming and immune evasion are two hallmarks of cancer. Metabolic
reprogramming is exemplified by cancer's propensity to utilize glucose at an exponential …

Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect

X Chen, L Li, Y Guan, J Yang, Y Cheng - Acta Pharmacologica Sinica, 2016 - nature.com
Tumor cells rely mainly on glycolysis for energy production even in the presence of sufficient
oxygen, a phenomenon termed the Warburg effect, which is the most outstanding …

Cancer cell metabolism: implications for therapeutic targets

M Jang, SS Kim, J Lee - Experimental & molecular medicine, 2013 - nature.com
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a
phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in …