Biocompatible polymeric nanoparticles degrade and release cargo in response to biologically relevant levels of hydrogen peroxide
C de Gracia Lux, S Joshi-Barr, T Nguyen… - Journal of the …, 2012 - ACS Publications
Oxidative stress is caused predominantly by accumulation of hydrogen peroxide and
distinguishes inflamed tissue from healthy tissue. Hydrogen peroxide could potentially be …
distinguishes inflamed tissue from healthy tissue. Hydrogen peroxide could potentially be …
Oxidation-accelerated hydrolysis of the ortho ester-containing acid-labile polymers
CC Song, R Ji, FS Du, DH Liang, ZC Li - ACS Macro Letters, 2013 - ACS Publications
We report a versatile method to tune the hydrolysis of the ortho ester-containing block
copolymers by covalently incorporating oxidation-sensitive phenylboronic ester units. A …
copolymers by covalently incorporating oxidation-sensitive phenylboronic ester units. A …
Physiologically relevant oxidative degradation of oligo (proline) cross-linked polymeric scaffolds
SS Yu, RL Koblin, AL Zachman, DS Perrien… - …, 2011 - ACS Publications
Chronic inflammation-mediated oxidative stress is a common mechanism of implant
rejection and failure. Therefore, polymer scaffolds that can degrade slowly in response to …
rejection and failure. Therefore, polymer scaffolds that can degrade slowly in response to …
Leveraging H2O2 Levels for Biomedical Applications
Hydrogen peroxide (H2O2)‐responsive materials have been employed as drug delivery or
diagnostic systems to treat or detect diseases with abnormal oxidative stress. A number of …
diagnostic systems to treat or detect diseases with abnormal oxidative stress. A number of …
Engineering intracellular delivery nanocarriers and nanoreactors from oxidation-responsive polymersomes via synchronized bilayer cross-linking and permeabilizing …
Reactive oxygen species (ROS) and oxidative stress are implicated in various physiological
and pathological processes, and this feature provides a vital biochemical basis for designing …
and pathological processes, and this feature provides a vital biochemical basis for designing …
Inflammation responsive logic gate nanoparticles for the delivery of proteins
EA Mahmoud, J Sankaranarayanan… - Bioconjugate …, 2011 - ACS Publications
Oxidative stress and reduced pH are important stimuli targets for intracellular delivery and
for delivery to diseased tissue. However, there is a dearth of materials able to deliver …
for delivery to diseased tissue. However, there is a dearth of materials able to deliver …
In vivo targeting of hydrogen peroxide by activatable cell-penetrating peptides
R Weinstain, EN Savariar, CN Felsen… - Journal of the American …, 2014 - ACS Publications
A hydrogen peroxide (H2O2)-activated cell-penetrating peptide was developed through
incorporation of a boronic acid-containing cleavable linker between polycationic cell …
incorporation of a boronic acid-containing cleavable linker between polycationic cell …
Collective activation of MRI agents via encapsulation and disease-triggered release
ML Viger, J Sankaranarayanan… - Journal of the …, 2013 - ACS Publications
An activation mechanism based on encapsulated ultrasmall gadolinium oxide nanoparticles
(Gd oxide NPs) in bioresponsive polymer capsules capable of triggered release in response …
(Gd oxide NPs) in bioresponsive polymer capsules capable of triggered release in response …
Glucose-oxidase based self-destructing polymeric vesicles
We have designed oxidation-responsive vesicles from synthetic amphiphilic block
copolymers (“polymersomes”) of ethylene glycol and propylene sulfide. Thioethers in the …
copolymers (“polymersomes”) of ethylene glycol and propylene sulfide. Thioethers in the …
Redox-responsive hydrogels for tunable and “On-demand” release of biomacromolecules
R Kilic Boz, D Aydin, S Kocak, B Golba… - Bioconjugate …, 2022 - ACS Publications
In recent years, stimuli-responsive degradation has emerged as a desirable design criterion
for functional hydrogels to tune the release of encapsulated payload as well as ensure …
for functional hydrogels to tune the release of encapsulated payload as well as ensure …