The overdue promise of short tandem repeat variation for heritability

MO Press, KD Carlson, C Queitsch - Trends in Genetics, 2014 - cell.com
Short tandem repeat (STR) variation has been proposed as a major explanatory factor in the
heritability of complex traits in humans and model organisms. However, we still struggle to …

Abundant contribution of short tandem repeats to gene expression variation in humans

M Gymrek, T Willems, A Guilmatre, H Zeng, B Markus… - Nature …, 2016 - nature.com
The contribution of repetitive elements to quantitative human traits is largely unknown. Here
we report a genome-wide survey of the contribution of short tandem repeats (STRs), which …

The impact of short tandem repeat variation on gene expression

SF Fotsing, J Margoliash, C Wang, S Saini, R Yanicky… - Nature …, 2019 - nature.com
Short tandem repeats (STRs) have been implicated in a variety of complex traits in humans.
However, genome-wide studies of the effects of STRs on gene expression thus far have had …

[HTML][HTML] WebSTR: a population-wide database of short tandem repeat variation in humans

OS Lundström, MA Verbiest, F Xia, HZ Jam… - Journal of molecular …, 2023 - Elsevier
Short tandem repeats (STRs) are consecutive repetitions of one to six nucleotide motifs.
They are hypervariable due to the high prevalence of repeat unit insertions or deletions …

The landscape of human STR variation

T Willems, M Gymrek, G Highnam, D Mittelman… - Genome …, 2014 - genome.cshlp.org
Short tandem repeats are among the most polymorphic loci in the human genome. These
loci play a role in the etiology of a range of genetic diseases and have been frequently …

STaRRRT: a table of short tandem repeats in regulatory regions of the human genome

KA Bolton, JP Ross, DM Grice, NA Bowden… - BMC genomics, 2013 - Springer
Abstract Background Tandem repeats (TRs) are unstable regions commonly found within
genomes that have consequences for evolution and disease. In humans, polymorphic TRs …

Tandem repeat polymorphisms: modulators of disease susceptibility and candidates for 'missing heritability'

AJ Hannan - Trends in genetics, 2010 - cell.com
A problem of 'missing heritability'has been identified following recent genome-wide
association (GWA) studies of single nucleotide polymorphisms (SNPs) associated with …

[PDF][PDF] Polymorphic short tandem repeats make widespread contributions to blood and serum traits

J Margoliash, S Fuchs, Y Li, X Zhang, A Massarat… - Cell Genomics, 2023 - cell.com
Short tandem repeats (STRs) are genomic regions consisting of repeated sequences of 1–6
bp in succession. Single-nucleotide polymorphism (SNP)-based genome-wide association …

Sequencing and characterizing short tandem repeats in the human genome

HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …

Characterization of genome-wide STR variation in 6487 human genomes

Y Shi, Y Niu, P Zhang, H Luo, S Liu, S Zhang… - Nature …, 2023 - nature.com
Short tandem repeats (STRs) are abundant and highly mutagenic in the human genome.
Many STR loci have been associated with a range of human genetic disorders. However …