Photodecaging of a mitochondria-localized iridium (III) endoperoxide complex for two-photon photoactivated therapy under hypoxia
Despite the clinical success of photodynamic therapy (PDT), the application of this medical
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …
technique is intrinsically limited by the low oxygen concentrations found in cancer tumors …
A mitochondrion‐localized two‐photon photosensitizer generating carbon radicals against hypoxic tumors
S Kuang, L Sun, X Zhang, X Liao… - Angewandte Chemie …, 2020 - Wiley Online Library
The efficacy of photodynamic therapy is typically reliant on the local concentration and
diffusion of oxygen. Due to the hypoxic microenvironment found in solid tumors, oxygen …
diffusion of oxygen. Due to the hypoxic microenvironment found in solid tumors, oxygen …
Endoplasmic reticulum-localized iridium (III) complexes as efficient photodynamic therapy agents via protein modifications
Protein inactivation by reactive oxygen species (ROS) such as singlet oxygen (1O2) and
superoxide radical (O2•–) is considered to trigger cell death pathways associated with …
superoxide radical (O2•–) is considered to trigger cell death pathways associated with …
Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir (iii) complexes
Herein we present a series of DCA-Ir (III) co-drug complexes that preferentially accumulate
in mitochondria and selectively cause cancer cell metabolic alterations and were found to …
in mitochondria and selectively cause cancer cell metabolic alterations and were found to …
A new near-infrared phosphorescent iridium (III) complex conjugated to a xanthene dye for mitochondria-targeted photodynamic therapy
Y Wu, J Wu, WY Wong - Biomaterials science, 2021 - pubs.rsc.org
Iridium (III) complexes are potent candidates for photodynamic therapy (PDT), but some key
drawbacks still hamper clinical translation, such as poor operability in the phototherapeutic …
drawbacks still hamper clinical translation, such as poor operability in the phototherapeutic …
Exploring the phototoxicity of hypoxic active iridium (III)-based sensitizers in 3D tumor spheroids
R Bevernaegie, B Doix, E Bastien… - Journal of the …, 2019 - ACS Publications
Among all molecules developed for anticancer therapies, photodynamic therapeutic agents
have a unique profile. Their maximal activity is specifically triggered in tumors by light, and …
have a unique profile. Their maximal activity is specifically triggered in tumors by light, and …
A biotinylated ruthenium (ii) photosensitizer for tumor-targeted two-photon photodynamic therapy
Platinum-resistant cancer cells are sensitive to changes in the levels of reactive oxidative
species (ROS). Herein, we design a biotin-modified Ru (II) complex as a photosensitizer …
species (ROS). Herein, we design a biotin-modified Ru (II) complex as a photosensitizer …
Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy
Z Zhang, Z Wei, J Guo, J Lyu, B Wang, G Wang… - Nature …, 2024 - nature.com
Practical photodynamic therapy calls for high-performance, less O2-dependent, long-
wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment …
wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment …
Ruthenium (II) polypyridyl complexes as mitochondria-targeted two-photon photodynamic anticancer agents
Clinical acceptance of photodynamic therapy is currently hindered by poor depth efficacy
and inefficient activation of the cell death machinery in cancer cells during treatment. To …
and inefficient activation of the cell death machinery in cancer cells during treatment. To …
A mitochondria-localized iridium (iii) photosensitizer for two-photon photodynamic immunotherapy against melanoma
Conventional photodynamic therapy mainly causes a therapeutic effect on the primary tumor
through the localized generation of reactive oxygen species, while metastatic tumors remain …
through the localized generation of reactive oxygen species, while metastatic tumors remain …