[HTML][HTML] Omics and male infertility: highlighting the application of transcriptomic data

TS Omolaoye, VA Omolaoye, RK Kandasamy… - Life, 2022 - mdpi.com
Male infertility is a multifaceted disorder affecting approximately 50% of male partners in
infertile couples. Over the years, male infertility has been diagnosed mainly through semen …

[HTML][HTML] Towards a multi-omics of male infertility

AO Wagner, A Turk, T Kunej - The world journal of men's health, 2023 - ncbi.nlm.nih.gov
Infertility is a common problem affecting one in six couples and in 30% of infertile couples,
the male factor is a major cause. A large number of genes are involved in spermatogenesis …

[HTML][HTML] Transcriptomic signatures for human male infertility

A Hodžić, A Maver, B Zorn, D Petrovič… - Frontiers in molecular …, 2023 - frontiersin.org
Introduction: Male infertility is a common, complex disorder. A better understanding of
pathogenesis and etiology is needed for timely diagnosis and treatment. The aim of this …

[HTML][HTML] Future diagnostics in male infertility: Genomics, epigenetics, metabolomics and proteomics

SC Krzastek, RP Smith, JR Kovac - Translational Andrology and …, 2020 - ncbi.nlm.nih.gov
A male factor is involved in 50% of couples with infertility. Unfortunately, the etiology of male
factor infertility remains classified as idiopathic in nearly 50% of cases. The semen analysis …

[HTML][HTML] Using publicly available transcriptomic data to identify mechanistic and diagnostic biomarkers in azoospermia and overall male infertility

TS Omolaoye, MY Hachim, SS du Plessis - Scientific reports, 2022 - nature.com
Azoospermia, which is the absence of spermatozoa in an ejaculate occurring due to defects
in sperm production, or the obstruction of the reproductive tract, affects about 1% of all men …

[HTML][HTML] The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility

JR Kovac, AW Pastuszak, DJ Lamb - Fertility and sterility, 2013 - Elsevier
Although male factors account for approximately 50% of all infertility, the mechanisms
underlying their origin are unknown. Currently, clinicians rely primarily on semen analyses …

[PDF][PDF] Multi-omics and male infertility: status, integration and future prospects

A Sinha, V Singh, S Yadav - Front Biosci (Schol Ed), 2017 - article.imrpress.com
Within the cell, gene expression analysis is the key to gain information about different
cellular and physiological events. The multifaceted route of fertilization is a combination of …

Recent insights on the significance of transcriptomic and metabolomic analysis of male factor infertility

LK Lee, KY Foo - Clinical biochemistry, 2014 - Elsevier
Infertility is a worldwide reproductive health problem which affects approximately 15% of
couples, with male factor infertility dominating nearly 50% of the affected population. The …

[HTML][HTML] A systematic review identifying fertility biomarkers in semen: a clinical approach through omics to diagnose male infertility

M Llavanera, A Delgado-Bermudez, J Ribas-Maynou… - Fertility and …, 2022 - Elsevier
Objective To identify the most robust molecular biomarkers in sperm and seminal plasma for
the diagnosis of male infertility, and to evaluate their clinical use. Design Systematic review …

Human male infertility: a complex multifactorial phenotype

K Singh, D Jaiswal - Reproductive sciences, 2011 - journals.sagepub.com
Infertility is a major reproductive health problem affecting 10% to 15% of couples, with
approximately equal contributions. Spermatogenesis is a dynamic and multistep process of …